Nucleophilic Trapping Nitrilimine Generated by Photolysis of Diaryltetrazole in Aqueous Phase
文献类型：期刊论文
| 作者 | Zhang, Yixin1,2,3; Liu, Wujun1,2; Zhao, Zongbao K.1,2 |
| 刊名 | molecules
 |
| 出版日期 | 2014 |
| 卷号 | 19期号:1页码:306-315 |
| 关键词 | photolysis tetrazole nucleophilic addition aqueous-phase reaction nitrilimine bioorthogonal reaction |
| 通讯作者 | 赵宗保 |
| 英文摘要 | nitrilimine generated by photolysis of diaryltetrazole in aqueous phase under mild conditions was trapped by nucleophiles including amines and thioalcohols. the representative products were characterized, while products with all 20 natural amino acids and a peptide were observed by maldi-tof mass spectroscopy. competitive studies showed that this reaction also occurred in the presence of acrylamide. these results provided new information for understanding the potential side reactions when tetrazole-alkene pairs were used as a bioorthogonal reaction in labeling proteins and related studies in buffered systems. |
| WOS标题词 | science & technology ; physical sciences |
| 学科主题 | 物理化学 |
| 类目[WOS] | chemistry, organic |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | 1,3-dipolar cycloaddition ; 2,5-disubstituted tetrazoles ; proteins ; imines ; photochemistry ; derivatives ; chemistry ; cells |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000334420300019 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/144044]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, Dalian 116023, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yixin,Liu, Wujun,Zhao, Zongbao K.. Nucleophilic Trapping Nitrilimine Generated by Photolysis of Diaryltetrazole in Aqueous Phase[J]. molecules,2014,19(1):306-315. |
| APA | Zhang, Yixin,Liu, Wujun,&Zhao, Zongbao K..(2014).Nucleophilic Trapping Nitrilimine Generated by Photolysis of Diaryltetrazole in Aqueous Phase.molecules,19(1),306-315. |
| MLA | Zhang, Yixin,et al."Nucleophilic Trapping Nitrilimine Generated by Photolysis of Diaryltetrazole in Aqueous Phase".molecules 19.1(2014):306-315. |
入库方式： OAI收割
来源：大连化学物理研究所
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