Cytotoxic biflavones from Stellera chamaejasme
文献类型：期刊论文
| 作者 | Wang, Zhi-xin1; Cheng, Meng-chun1; Zhang, Xiao-zhe1; Hong, Zhi-lai1; Gao, Ming-zhe1; Kan, Xiao-xi2; Li, Qi2; Wang, Ya-jie2; Zhu, Xiao-xin2; Xiao, Hong-bin1,2 |
| 刊名 | fitoterapia
 |
| 出版日期 | 2014-12-01 |
| 卷号 | 99期号:1页码:334-340 |
| 关键词 | Stellera chamaejasme Chamaejasmenin E Chamaejasmin D LCD Cytotoxic activity |
| 通讯作者 | 肖红斌 |
| 英文摘要 | bioassay-guided phytochemical studies on stellera chamaejasme led to the isolation of two new biflavones, chamaejasmenin e (1) and chamaejasmin d (2), together with ten known compounds. the structures of new compounds were elucidated by extensive spectroscopic analyses and their absolute configurations on 2, 3, 2 '' and 3 '' were confirmed by tddft quantum chemical calculated ecd spectra combined with experimental ecd spectra. all isolated biflavones were evaluated for their cytotoxic activities against bel-7402 and a549 tumor cell lines, and sikokianin d (3) was found to possess the most potential cytotoxic activities against both the two cell lines with ic50 values of 1.29 +/- 021 and 0.75 +/- 025 mu m, respectively. moreover, some structure function relationships of these bioflavones for cytotoxic activities were explored and summarized. (c) 2014 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 学科主题 | 物理化学 |
| 类目[WOS] | chemistry, medicinal ; pharmacology & pharmacy |
| 研究领域[WOS] | pharmacology & pharmacy |
| 关键词[WOS] | circular-dichroism ; neochamaejasmin-a ; cancer-cells ; flavonoids ; apoptosis ; biflavanones ; cycle |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000347019000042 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/144159]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Zhi-xin,Cheng, Meng-chun,Zhang, Xiao-zhe,et al. Cytotoxic biflavones from Stellera chamaejasme[J]. fitoterapia,2014,99(1):334-340. |
| APA | Wang, Zhi-xin.,Cheng, Meng-chun.,Zhang, Xiao-zhe.,Hong, Zhi-lai.,Gao, Ming-zhe.,...&Xiao, Hong-bin.(2014).Cytotoxic biflavones from Stellera chamaejasme.fitoterapia,99(1),334-340. |
| MLA | Wang, Zhi-xin,et al."Cytotoxic biflavones from Stellera chamaejasme".fitoterapia 99.1(2014):334-340. |
入库方式： OAI收割
来源：大连化学物理研究所
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