Serum Metabolomics Study and Eicosanoid Analysis of Childhood Atopic Dermatitis Based on Liquid Chromatography-Mass Spectrometry
文献类型：期刊论文
| 作者 | Huang, Yan1; Chen, Guoyou2,3; Liu, Xinyu2; Shao, Yaping2; Gao, Peng2; Xin, Chenchen1; Cui, Zhenze1; Zhao, Xinjie2; Xu, Guowang2 |
| 刊名 | journal of proteome research
 |
| 出版日期 | 2014-12-01 |
| 卷号 | 13期号:12页码:5715-5723 |
| 关键词 | Atopic dermatitis metabolomics eicosanoids immunoglobulin E LC-MS |
| 通讯作者 | 赵欣捷 |
| 英文摘要 | atopic dermatitis (ad) is the most common inflammatory skin disease in children. in the study, ultra high performance liquid chromatographymass spectrometry was used to investigate serum metabolic abnormalities of ad children. two batch fasting sera were collected from ad children and healthy control; one of them was for nontargeted metabolomics analysis, the other for targeted eicosanoids analysis. ad children were divided into high immunoglobulin e (ige) group and normal ige group. on the basis of the two analysis approaches, it was found that the differential metabolites of ad, leukotriene b4, prostaglandins, conjugated bile acids, etc., were associated with inflammatory response and bile acids metabolism. carnitines, free fatty acids, lactic acid, etc., increased in the ad group with high ige, which revealed energy metabolism disorder. amino acid metabolic abnormalities and increased levels of cytochrome p450 epoxygenase metabolites were found in the ad group with normal ige. the results provided a new perspective to understand the mechanism and find potential biomarkers of ad and may provide a new reference for personalized treatment. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 学科主题 | 物理化学 |
| 类目[WOS] | biochemical research methods |
| 研究领域[WOS] | biochemistry & molecular biology |
| 关键词[WOS] | stratum-corneum lipids ; chain amino-acids ; nitric-oxide ; arachidonic-acid ; mitochondrial dysfunction ; intestinal inflammation ; skin inflammation ; disease ; polymorphisms ; accumulation |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000346039400037 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/144196]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Dalian Childrens Hosp, Dalian 116011, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 3.Harbin Med Univ, Dept Pharm, Daqing 163319, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Yan,Chen, Guoyou,Liu, Xinyu,et al. Serum Metabolomics Study and Eicosanoid Analysis of Childhood Atopic Dermatitis Based on Liquid Chromatography-Mass Spectrometry[J]. journal of proteome research,2014,13(12):5715-5723. |
| APA | Huang, Yan.,Chen, Guoyou.,Liu, Xinyu.,Shao, Yaping.,Gao, Peng.,...&Xu, Guowang.(2014).Serum Metabolomics Study and Eicosanoid Analysis of Childhood Atopic Dermatitis Based on Liquid Chromatography-Mass Spectrometry.journal of proteome research,13(12),5715-5723. |
| MLA | Huang, Yan,et al."Serum Metabolomics Study and Eicosanoid Analysis of Childhood Atopic Dermatitis Based on Liquid Chromatography-Mass Spectrometry".journal of proteome research 13.12(2014):5715-5723. |
入库方式： OAI收割
来源：大连化学物理研究所
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