Current state-of-the-art of nontargeted metabolomics based on liquid chromatography-mass spectrometry with special emphasis in clinical applications
文献类型：期刊论文
| 作者 | Yin, Peiyuan; Xu, Guowang |
| 刊名 | journal of chromatography a
 |
| 出版日期 | 2014-12-29 |
| 卷号 | 1374期号:1页码:1-13 |
| 关键词 | Metabolomics Metabolic profiling LC-MS Metabolite coverage Pseudo-targeted method |
| 通讯作者 | 许国旺 |
| 英文摘要 | metabolomics, as a part of systems biology, has been widely applied in different fields of life science by studying the endogenous metabolites. the development and applications of liquid chromatography (lc) coupled with high resolution mass spectrometry (ms) greatly improve the achievable data quality in non-targeted metabolic profiling. however, there are still some emerging challenges to be covered in lc-ms based metabolomics. here, recent approaches about sample collection and preparation, instrumental analysis, and data handling of lc-ms based metabolomics are summarized, especially in the analysis of clinical samples. emphasis is put on the improvement of analytical techniques including the combination of different lc columns, isotope coded derivatization methods, pseudo-targeted lc-ms method, new data analysis algorithms and structural identification of important metabolites. (c) 2014 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 学科主题 | 物理化学 |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | solid-phase microextraction ; ms-based metabolomics ; gestational diabetes-mellitus ; functional genomics tool ; global systems biology ; human blood-plasma ; tert-butyl ether ; lc-ms ; metabolite identification ; sample preparation |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000347605000001 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/144198]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, Peiyuan,Xu, Guowang. Current state-of-the-art of nontargeted metabolomics based on liquid chromatography-mass spectrometry with special emphasis in clinical applications[J]. journal of chromatography a,2014,1374(1):1-13. |
| APA | Yin, Peiyuan,&Xu, Guowang.(2014).Current state-of-the-art of nontargeted metabolomics based on liquid chromatography-mass spectrometry with special emphasis in clinical applications.journal of chromatography a,1374(1),1-13. |
| MLA | Yin, Peiyuan,et al."Current state-of-the-art of nontargeted metabolomics based on liquid chromatography-mass spectrometry with special emphasis in clinical applications".journal of chromatography a 1374.1(2014):1-13. |
入库方式： OAI收割
来源：大连化学物理研究所
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