Amide Alkaloids from Scopolia tangutica
文献类型：期刊论文
| 作者 | Long, Zhen1; Zhang, Yan2; Guo, Zhimou1; Wang, Lien2; Xue, Xingya1; Zhang, Xiuli1; Wang, Shisheng3; Wang, Zhiwei2; Civelli, Olivier2; Liang, Xinmiao1 |
| 刊名 | planta medica
 |
| 出版日期 | 2014-08-01 |
| 卷号 | 80期号:13页码:1124-1130 |
| 关键词 | Scopolia tangutica Solanaceae alkaloid hydroxycinnamic acid amide mu-opioid receptor |
| 通讯作者 | 梁鑫淼 ; 张秀莉 |
| 英文摘要 | four new hydroxycinnamic acid amides, scotanamines a-d (1-4), and seven known alkaloids, including n-1,n-10-di-dihydrocaffeoylspermidine (5), scopolamine (6), anisodamine (7), hyoscyamine (8), anisodine (9), caffeoylputrescine (10), and n-1-caffeoyl-n-3-dihydrocaffeoylspermidine (11), were obtained from the roots of scopolia tangutica. the present study represents the first recognition of hydroxycinnamic acid amides containing putrescine or spermidine in s. tangutica. compound 1, in particular, contains a moiety resulting from the condensation of nortropinone and putrescine. compound 2 exhibited moderate agonist activity at the mu-opioid receptor (ec50 = 7.3 mu m). compound 2 was tested in vivo and induced analgesia in mice. the analgesic effect was recorded using the tail-flick assay and was reversed by naloxone. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 学科主题 | 物理化学 |
| 类目[WOS] | plant sciences ; chemistry, medicinal ; pharmacology & pharmacy |
| 研究领域[WOS] | plant sciences ; pharmacology & pharmacy |
| 关键词[WOS] | phenolic-compounds ; tropane alkaloids ; nicotiana-tabacum ; lycium-chinense ; caffeoylputrescine ; anisodamine ; spectroscopy ; scopolamine ; pain |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000341581600010 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/144341]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Separat Sci Analyt Chem, Dalian Inst Chem Phys, Key Lab Nat Med, Dalian 116023, Peoples R China 2.Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92717 USA 3.Dalian Univ Technol, Sch Pharmaceut Sci & Technol, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Long, Zhen,Zhang, Yan,Guo, Zhimou,et al. Amide Alkaloids from Scopolia tangutica[J]. planta medica,2014,80(13):1124-1130. |
| APA | Long, Zhen.,Zhang, Yan.,Guo, Zhimou.,Wang, Lien.,Xue, Xingya.,...&Liang, Xinmiao.(2014).Amide Alkaloids from Scopolia tangutica.planta medica,80(13),1124-1130. |
| MLA | Long, Zhen,et al."Amide Alkaloids from Scopolia tangutica".planta medica 80.13(2014):1124-1130. |
入库方式： OAI收割
来源：大连化学物理研究所
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