Gd-Al co-doped mesoporous silica nanoparticles loaded with Ru(bpy)(3)(2+) as a dual-modality probe for fluorescence and magnetic resonance imaging
文献类型：期刊论文
| 作者 | Zhang, Dan1,2; Gao, Ai1,2; Xu, Yang1,2; Yin, Xue-Bo1,2; He, Xi-Wen1,2; Zhang, Yu-Kui1,2,3 |
| 刊名 | analyst
 |
| 出版日期 | 2014-09-21 |
| 卷号 | 139期号:18页码:4613-4619 |
| 通讯作者 | xueboyin |
| 英文摘要 | mesoporous silica nanoparticles (msns) were co-doped with gd3+ and al3+ and then loaded with ru(bpy)(3)(2+) by ion-exchange to prepare ru/gd-al@msns. the as-prepared ru/gd-al@msns were applied as contrast agents for in vivo fluorescence and magnetic resonance (mr) dual-modality imaging with a mouse as a model. the effects of al3+ and msns on longitudinal relaxivity (r(1)) and fluorescence were investigated using a series of gd-containing silica nanoparticles, including gd@msns, gd-al@msns, and ru/gd-al@nonporous silica nanoparticles. co-doping with al3+ improved the loading of gd3+; the mesoporous structure improved the water exchange rate. the improvement enhanced the mr imaging efficiency of the ru/gd-al@msn probe. a higher relaxivity (19.2 mm(-1) s(-1)) was observed compared to that from a commercial contrast agent, gd-diethylene triamine pentaacetic acid (gddtpa). importantly, the mesoporous structure provided a large specific surface area for the loading of ru(bpy)(3)(2+) by a simple ion-exchange procedure. intense red fluorescence was observed from ru/gd-al@msn probes. the versatility of ru/gd-al@msns for dual-modality imaging was demonstrated using in vivo fluorescence imaging and t-1-weighted mr imaging with a mouse model. the nanoparticles are biocompatible and may be attractive for clinical applications. |
| 学科主题 | 物理化学 |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, analytical |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | contrast agents ; suspensions ; particles ; toxicity ; mice |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000340755000028 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/144452]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Nankai Univ, Coll Chem, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China 2.Nankai Univ, Coll Chem, Res Ctr Analyt Sci, Tianjin 300071, Peoples R China 3.Chinese Acad Sci, Nat Chromatog R&A Ctr, Dalian Inst Chem Phys, Dalian 116011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Dan,Gao, Ai,Xu, Yang,et al. Gd-Al co-doped mesoporous silica nanoparticles loaded with Ru(bpy)(3)(2+) as a dual-modality probe for fluorescence and magnetic resonance imaging[J]. analyst,2014,139(18):4613-4619. |
| APA | Zhang, Dan,Gao, Ai,Xu, Yang,Yin, Xue-Bo,He, Xi-Wen,&Zhang, Yu-Kui.(2014).Gd-Al co-doped mesoporous silica nanoparticles loaded with Ru(bpy)(3)(2+) as a dual-modality probe for fluorescence and magnetic resonance imaging.analyst,139(18),4613-4619. |
| MLA | Zhang, Dan,et al."Gd-Al co-doped mesoporous silica nanoparticles loaded with Ru(bpy)(3)(2+) as a dual-modality probe for fluorescence and magnetic resonance imaging".analyst 139.18(2014):4613-4619. |
入库方式： OAI收割
来源：大连化学物理研究所
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