Monodisperse Boronate Polymeric Particles Synthesized by a Precipitation Polymerization Strategy: Particle Formation and Glycoprotein Response from the Standpoint of the Flory-Huggins Model
文献类型：期刊论文
| 作者 | Liu, Jianxi1,2; Qu, Yanyan1,2; Yang, Kaiguang1; Wu, Qi1,2; Shan, Yichu1; Zhang, Lihua1; Liang, Zhen1; Zhang, Yukui1 |
| 刊名 | acs applied materials & interfaces
 |
| 出版日期 | 2014-02-12 |
| 卷号 | 6期号:3页码:2059-2066 |
| 关键词 | one pot polymerization glycoprotein response boronate affinity Flory-Huggins model |
| 通讯作者 | 张丽华 |
| 英文摘要 | the development of a highly specific recognition system for glycoprotein capture from complex biological samples is a prerequisite to the success of mass spectra-based glycoproteomics analysis. to achieve this purpose, a one-pot precipitation polymerization (pp) strategy with a novel solvent system composed of water/ethanol (4:1, v/v) is described for preparing boronate-affinity polymeric micro/nano particles using 4-vinylphenylboronic acid (vpba) as the functional monomer and n,n'-methylenebis(acrylamide) (mba) alone or together with divinylbenzene (dvb) as the cross-linker(s). the proposed polymerization strategy not only affords monodisperse polymeric submicrometer particles with a smooth surface and controllable size, ranging from 300 to 700 nm, but also increases the loading capacity of boronic acid, which could hardly be achieved by other polymerization methods, thus leading to the specific recognition of glycoproteins. the effects of solvent systems and monomers on the morphology and boronate-affinity capacity of prepared materials were further investigated based on the flory-huggins model. it was proved that the reaction rate of various monomers during particle formation might be the key factor affecting the affinity capacity for glycoproteins. our results demonstrated that under the theoretical guidance of the flory-huggins model the pp strategy with a selected monomer and solvent system might provide a good approach to prepare submicrometer polymer particles with plenty of boronic acid groups on the surface to achieve a highly selective enrichment of glycoproteins. |
| WOS标题词 | science & technology ; technology |
| 学科主题 | 物理化学 |
| 类目[WOS] | nanoscience & nanotechnology ; materials science, multidisciplinary |
| 研究领域[WOS] | science & technology - other topics ; materials science |
| 关键词[WOS] | block-copolymers ; physiological ph ; acid ; microspheres ; nanoparticles ; enrichment ; release ; glycopeptides ; composites ; microgels |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000331493200096 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/144460]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Jianxi,Qu, Yanyan,Yang, Kaiguang,et al. Monodisperse Boronate Polymeric Particles Synthesized by a Precipitation Polymerization Strategy: Particle Formation and Glycoprotein Response from the Standpoint of the Flory-Huggins Model[J]. acs applied materials & interfaces,2014,6(3):2059-2066. |
| APA | Liu, Jianxi.,Qu, Yanyan.,Yang, Kaiguang.,Wu, Qi.,Shan, Yichu.,...&Zhang, Yukui.(2014).Monodisperse Boronate Polymeric Particles Synthesized by a Precipitation Polymerization Strategy: Particle Formation and Glycoprotein Response from the Standpoint of the Flory-Huggins Model.acs applied materials & interfaces,6(3),2059-2066. |
| MLA | Liu, Jianxi,et al."Monodisperse Boronate Polymeric Particles Synthesized by a Precipitation Polymerization Strategy: Particle Formation and Glycoprotein Response from the Standpoint of the Flory-Huggins Model".acs applied materials & interfaces 6.3(2014):2059-2066. |
入库方式： OAI收割
来源：大连化学物理研究所
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