Blood volatile compounds as biomarkers for colorectal cancer
文献类型：期刊论文
| 作者 | Wang, Changsong1; Li, Peng1; Lian, Ailing1; Sun, Bo1; Wang, Xiaoyang1; Guo, Lei1; Chi, Chunjie1; Liu, Shanshan1; Zhao, Wei1; Luo, Suqi1 |
| 刊名 | cancer biology & therapy
 |
| 出版日期 | 2014-02-01 |
| 卷号 | 15期号:2页码:200-206 |
| 关键词 | colorectal cancer biomarkers volatile organic compounds solid-phase microextraction cancer diagnosis |
| 通讯作者 | 李恩有 |
| 英文摘要 | many recent studies have focused on the connection between the composition of specific volatile organic compounds (vocs) in exhaled breath and various forms of cancer. however, the composition of exhaled breath is affected by many factors, such as lung disease, smoking, and diet. vocs are released into the bloodstream before they are exhaled; therefore, the analysis of vocs in blood will provide more accurate results than the analysis of vocs in exhaled breath. blood were collected from 16 colorectal cancer patients and 20 healthy controls, then solid phase microextraction-chromatography-mass spectrometry (spme-gc-ms) was used to analysis the exhaled volatile organic compounds (vocs). the statistical methods principal component analysis (pca) and partial least-squares discriminant analysis (plsda) were performed to deal with the final dates. three metabolic biomarkers were found at significantly lower levels in the group of crc patients than in the normal control group (p < 0.01): phenyl methylcarbamate, ethylhexanol, and 6-t-butyl-2,2,9,9-tetramethyl-3,5-decadien-7-yne. in addition, significantly higher levels of 1,1,4,4-tetramethyl-2,5-dimethylene-cyclohexane were found in the group of crc patients than in the normal control group (p < 0.05). compared with healthy individuals, patients with colorectal adenocarcinoma exhibited a distinct blood metabolic profile with respect to vocs. the analysis of blood vocs appears to have potential clinical applications for crc screening. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 学科主题 | 物理化学 |
| 类目[WOS] | oncology |
| 研究领域[WOS] | oncology |
| 关键词[WOS] | organic-compounds ; lung-cancer ; molecular biomarkers ; lipid-peroxidation ; gastric-cancer ; breath ; disease ; spectrometry ; expression ; diagnosis |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000331333200008 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/144474]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Harbin Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Harbin, Peoples R China 2.Harbin Med Univ, Sch Publ Hlth, Dept Biostat, Harbin, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China 4.Harbin Med Univ, Dept Microbiol, Heilongjiang Key Lab Immun & Infect, Harbin, Peoples R China 5.Harbin Med Univ, Minist Educ, Key Lab Biopharmaceut, Harbin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Changsong,Li, Peng,Lian, Ailing,et al. Blood volatile compounds as biomarkers for colorectal cancer[J]. cancer biology & therapy,2014,15(2):200-206. |
| APA | Wang, Changsong.,Li, Peng.,Lian, Ailing.,Sun, Bo.,Wang, Xiaoyang.,...&Li, Enyou.(2014).Blood volatile compounds as biomarkers for colorectal cancer.cancer biology & therapy,15(2),200-206. |
| MLA | Wang, Changsong,et al."Blood volatile compounds as biomarkers for colorectal cancer".cancer biology & therapy 15.2(2014):200-206. |
入库方式： OAI收割
来源：大连化学物理研究所
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