The lipid profile of brown adipose tissue is sex-specific in mice
文献类型：期刊论文
| 作者 | Hoene, Miriam1; Li, Jia4; Haering, Hans-Ulrich1,2,3; Weigert, Cora1,2,3; Xu, Guowang4; Lehmann, Rainer1,2,3 |
| 刊名 | biochimica et biophysica acta-molecular and cell biology of lipids
 |
| 出版日期 | 2014-10-01 |
| 卷号 | 1841期号:10页码:1563-1570 |
| 关键词 | Brown adipose tissue White adipose tissue Gonadal fat Subcutaneous fat Female and male mice Tandem-MS lipidomics |
| 通讯作者 | 许国旺 ; rainerlehmann |
| 英文摘要 | brown adipose tissue (bat) is a thermogenic organ with a vital function in small mammals and potential as metabolic drug target in humans. by using high-resolution lc-tandem-mass spectrometry, we quantified 329 lipid species from 17 (sub)classes and identified the fatty acid composition of all phospholipids from bat and subcutaneous and gonadal white adipose tissue (wat) from female and male mice. phospholipids and free fatty acids were higher in bat, while dag and tag levels were higher in wat. a set of phospholipids dominated by the residue docosahexaenoic acid, which influences membrane fluidity, showed the highest specificity for bat. we additionally detected major sex-specific differences between the bat lipid profiles, while samples from the different wat depots were comparatively similar. female bat contained less triacylglycerol and more phospholipids rich in arachidonic and stearic acid whereas another set of fatty acid residues that included linoleic and palmitic acid prevailed in males. these differences in phospholipid fatty acid composition could greatly affect mitochondrial membranes and other cellular organelles and thereby regulate the function of bat in a sex-specific manner. (c) 2014 the authors. published by elsevier b.v. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 学科主题 | 物理化学 |
| 类目[WOS] | biochemistry & molecular biology ; biophysics ; cell biology |
| 研究领域[WOS] | biochemistry & molecular biology ; biophysics ; cell biology |
| 关键词[WOS] | fatty-acid-composition ; docosahexaenoic acid ; insulin sensitivity ; cold-acclimation ; mitochondrial biogenesis ; eicosapentaenoic acid ; dependent differences ; uncoupling protein ; adult humans ; rats |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000342864900025 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/144475]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Univ Tubingen Hosp, Dept Internal Med 4, Div Clin Chem & Pathobiochem, Tubingen, Germany 2.Univ Tubingen, Helmholtz Ctr Munich, Inst Diabet Res & Metab Dis, Tubingen, Germany 3.German Ctr Diabet Res DZD, Tubingen, Germany 4.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hoene, Miriam,Li, Jia,Haering, Hans-Ulrich,et al. The lipid profile of brown adipose tissue is sex-specific in mice[J]. biochimica et biophysica acta-molecular and cell biology of lipids,2014,1841(10):1563-1570. |
| APA | Hoene, Miriam,Li, Jia,Haering, Hans-Ulrich,Weigert, Cora,Xu, Guowang,&Lehmann, Rainer.(2014).The lipid profile of brown adipose tissue is sex-specific in mice.biochimica et biophysica acta-molecular and cell biology of lipids,1841(10),1563-1570. |
| MLA | Hoene, Miriam,et al."The lipid profile of brown adipose tissue is sex-specific in mice".biochimica et biophysica acta-molecular and cell biology of lipids 1841.10(2014):1563-1570. |
入库方式： OAI收割
来源：大连化学物理研究所
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