Metabolic profiling study of early and late recurrence of hepatocellular carcinoma based on liquid chromatography-mass spectrometry
文献类型：期刊论文
| 作者 | Zhou, Lina1; Liao, Yuan2; Yin, Peiyuan1; Zeng, Zhongda1; Li, Jia1; Lu, Xin1; Zheng, Limin2; Xu, Guowang1 |
| 刊名 | journal of chromatography b-analytical technologies in the biomedical and life sciences
 |
| 出版日期 | 2014-09-01 |
| 卷号 | 966期号:1页码:163-170 |
| 关键词 | Metabolic profiling Hepatocellular carcinoma Curative resection Early recurrence Metabolomics |
| 通讯作者 | 许国旺 |
| 英文摘要 | the objectives of this pilot study were to predict early postoperative recurrence in hepatocellular carcinoma (hcc) patients based on metabolic features and to explore the related metabolic disturbances. liquid chromatography-mass spectrometry-based metabolic profiling was performed on the plasma of 18 late recurrent and 22 early recurrent hcc patients. metabolic differences were found to be related to amino acid, bile acid, cholesterol, fatty acid, phospholipid and carbohydrate metabolism. bile acids, steroids and fatty acids showed significant variation in the early recurrent hcc group compared to the late recurrence group. decreased levels of polyunsaturated eicosapentaenoic acid, docosahexaenoic acid and linolenic acid were found to be specific metabolic features for early recurrence. with the combination of methionine, gcdca and cholesterol sulfate, 85% of the early recurrent hccs can be predicted correctly with the corresponding area under the curve (auc) equal to 0.95 in the training set, and 80% of the early recurrent hccs can be predicted correctly with the corresponding auc equal to 0.91 in the test set. (c) 2014 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 学科主题 | 物理化学 |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | late intrahepatic recurrence ; risk-factors ; curative resection ; liver-cirrhosis ; prediction ; biomarkers ; hepatectomy ; invasion ; outcomes ; single |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000340323200020 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/144487]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Sun Yat Sen Zhongshan Univ, State Key Lab Oncol South China, Guangzhou, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Lina,Liao, Yuan,Yin, Peiyuan,et al. Metabolic profiling study of early and late recurrence of hepatocellular carcinoma based on liquid chromatography-mass spectrometry[J]. journal of chromatography b-analytical technologies in the biomedical and life sciences,2014,966(1):163-170. |
| APA | Zhou, Lina.,Liao, Yuan.,Yin, Peiyuan.,Zeng, Zhongda.,Li, Jia.,...&Xu, Guowang.(2014).Metabolic profiling study of early and late recurrence of hepatocellular carcinoma based on liquid chromatography-mass spectrometry.journal of chromatography b-analytical technologies in the biomedical and life sciences,966(1),163-170. |
| MLA | Zhou, Lina,et al."Metabolic profiling study of early and late recurrence of hepatocellular carcinoma based on liquid chromatography-mass spectrometry".journal of chromatography b-analytical technologies in the biomedical and life sciences 966.1(2014):163-170. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。