A novel surface-confined glucaminium-based ionic liquid stationary phase for hydrophilic interaction/anion-exchange mixed-mode chromatography
文献类型：期刊论文
| 作者 | Qiao, Lizhen; Wang, Shuangyuan; Li, Hua; Shan, Yuanhong; Dou, Abo; Shi, Xianzhe; Xu, Guowang |
| 刊名 | journal of chromatography a
 |
| 出版日期 | 2014-09-19 |
| 卷号 | 1360期号:1页码:240-247 |
| 关键词 | Glucaminium-based ionic liquid Hydrophilic interaction chromatography Anion-exchange Stationary phase |
| 通讯作者 | 石先哲 ; 许国旺 |
| 英文摘要 | glucaminium-based ionic liquids are a new class of recently developed ionic liquids and prepared by functionalizing the amine group of n-methyl-d-glucamine, which renders them good hydrophilicity due to the presence of the glucose structure and charged quaternary ammonium group. in the present study, a glucaminium-based ionic liquid n,n-diallyl-n-methyl-d-glucaminium bromide was synthesized and subsequently bonded to the surface of 3-mercaptopropyl modified silica materials through "thiol-ene" click chemistry. the obtained stationary phase was characterized by elemental analysis and infrared spectroscopy, and then packed as a hplc column. a mixture of five nucleosides was used to characterize the separation performance of the obtained column under hilic mode and the column efficiency was determined with cytidine as the test solute, reaching 80,000 plates/m. then, the retention behavior was evaluated by investigating the effect of various chromatographic factors on retention of different types of solutes, and the results revealed that the developed surface-confined glucaminium-based ionic liquid stationary phase exhibited a hydrophilic interaction/anion-exchange mixed-mode retention mechanism. finally, two mixtures of nucleotides and flavonoids were separated on the glucaminium-based ionic liquid column, respectively under hydrophilic interaction and hydrophilic interaction/anion-exchange mixed-mode chromatography. in conclusion, the multimodal retention capabilities of the glucaminium-based ionic liquid column could offer a wider range of retention behavior and flexible selectivity toward polar and hydrophilic compounds. (c) 2014 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 学科主题 | 物理化学 |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | solvation energy relationships ; reversed-phase ; phenolic-acids ; separation ; performance ; retention ; selectivity ; extraction ; flavonoids ; chemistry |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000341469400025 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/144488]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qiao, Lizhen,Wang, Shuangyuan,Li, Hua,et al. A novel surface-confined glucaminium-based ionic liquid stationary phase for hydrophilic interaction/anion-exchange mixed-mode chromatography[J]. journal of chromatography a,2014,1360(1):240-247. |
| APA | Qiao, Lizhen.,Wang, Shuangyuan.,Li, Hua.,Shan, Yuanhong.,Dou, Abo.,...&Xu, Guowang.(2014).A novel surface-confined glucaminium-based ionic liquid stationary phase for hydrophilic interaction/anion-exchange mixed-mode chromatography.journal of chromatography a,1360(1),240-247. |
| MLA | Qiao, Lizhen,et al."A novel surface-confined glucaminium-based ionic liquid stationary phase for hydrophilic interaction/anion-exchange mixed-mode chromatography".journal of chromatography a 1360.1(2014):240-247. |
入库方式： OAI收割
来源：大连化学物理研究所
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