Noninvasive detection of colorectal cancer by analysis of exhaled breath
文献类型：期刊论文
| 作者 | Wang, Changsong1,4,5; Ke, Chaofu2; Wang, Xiaoyang1; Chi, Chunjie1; Guo, Lei1; Luo, Suqi1; Guo, Zhigang1; Xu, Guowang3; Zhang, Fengmin4,5; Li, Enyou1 |
| 刊名 | analytical and bioanalytical chemistry
 |
| 出版日期 | 2014-07-01 |
| 卷号 | 406期号:19页码:4757-4763 |
| 关键词 | Biomarkers Cancer diagnosis Colorectal cancer Solid-phase microextraction Volatile organic compounds |
| 通讯作者 | 李恩有 |
| 英文摘要 | there has been growing interest in exhaled breath analysis for cancer screening and disease monitoring; however, limited breath biomarker information exists regarding colorectal cancer (crc). the objective of this study was to screen for breath biomarkers of crc. exhaled breath was collected from 20 crc patients and 20 healthy controls; subsequently, solid-phase microextraction-gas chromatography/mass spectrometry (spme-gc/ms) was used to assess the exhaled volatile organic compounds (vocs) of the study participants. the statistical methods of principal component analysis (pca) and partial least squares discriminant analysis (pls-da) were performed to process the final data. the vocs in the exhalations of crc patients exhibited significant differences from the vocs in the exhalations of healthy controls; in particular, relative to the latter exhalations, the former exhalations contain significantly higher levels of cyclohexanone, 2,2-dimethyldecane, dodecane, 4-ethyl-1-octyn-3-ol, ethylaniline, cyclooctylmethanol, trans-2-dodecen-1-ol, and 3-hydroxy-2,4,4-trimethylpentyl 2-methylpropanoate but significantly lower levels of 6-t-butyl-2,2,9,9-tetramethyl-3,5-decadien-7-yne (p < 0.05). analyses of breath vocs provide a related model of crc exhalation that could represent an effective and convenient screening method for this disease. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 学科主题 | 物理化学 |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | volatile organic-compounds ; lung-cancer ; molecular biomarkers ; in-vitro ; spectrometry ; diet |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000339155500019 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/144499]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Harbin Med Univ, Dept Anesthesiol, Affiliated Hosp 1, Harbin 150001, Peoples R China 2.Harbin Med Univ, Sch Publ Hlth, Dept Biostat, Harbin 150081, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 4.Harbin Med Univ, Heilongjiang Key Lab Immun & Infect, Dept Microbiol, Harbin 150081, Peoples R China 5.Harbin Med Univ, Minist Educ, Key Lab Biopharmaceut, Harbin 150081, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Changsong,Ke, Chaofu,Wang, Xiaoyang,et al. Noninvasive detection of colorectal cancer by analysis of exhaled breath[J]. analytical and bioanalytical chemistry,2014,406(19):4757-4763. |
| APA | Wang, Changsong.,Ke, Chaofu.,Wang, Xiaoyang.,Chi, Chunjie.,Guo, Lei.,...&Li, Enyou.(2014).Noninvasive detection of colorectal cancer by analysis of exhaled breath.analytical and bioanalytical chemistry,406(19),4757-4763. |
| MLA | Wang, Changsong,et al."Noninvasive detection of colorectal cancer by analysis of exhaled breath".analytical and bioanalytical chemistry 406.19(2014):4757-4763. |
入库方式： OAI收割
来源：大连化学物理研究所
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