Self-assembly-induced near-infrared fluorescent nanoprobes for effective tumor molecular imaging
文献类型：期刊论文
| 作者 | Wu, Hao1,2; Zhao, Haidong3; Song, Xiaojie1,2; Li, Shen1,2; Ma, Xiaojun1; Tan, Mingqian1 |
| 刊名 | journal of materials chemistry b
 |
| 出版日期 | 2014-08-28 |
| 卷号 | 2期号:32页码:5302-5308 |
| 通讯作者 | 马小军 ; 谭明乾 |
| 英文摘要 | fabrication of near-infrared (nir) fluorescent nanoprobes (nps) has drawn great attention due to their potential as highly sensitive optical probes for in vivo tumor molecular imaging. herein, a facile strategy has been reported for the preparation of ultrasmall (<20 nm) indocyanine green (icg)-containing nir fluorescent nps using self-assembly chemistry between folate (fa) modified water-soluble chitosan (wcs) and icg. the icg-containing nps exhibit characteristics of crystalline solid, good photostability, low cytotoxicity and high tumor targeting ability for in vitro cell imaging. we also explored this system for in vivo tumor molecular imaging. significant tumor accumulation was observed for both in vitro and in vivo tumor imaging in hela tumor cell imaging and xenograft-bearing mice model (2 mu mol kg(-1) at 48 and 72 h time points). the availability of these self-assembled nir nps provides a convenient tool for tumor imaging and detection. |
| WOS标题词 | science & technology ; technology |
| 学科主题 | 物理化学 |
| 类目[WOS] | materials science, biomaterials |
| 研究领域[WOS] | materials science |
| 关键词[WOS] | indocyanine-green ; silica nanoparticles ; contrast agent ; in-vitro ; chitosan ; cancer ; biodistribution ; micelles ; surgery ; systems |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000340076100020 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/144519]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Dalian Med Univ, Affiliated Hosp 2, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Hao,Zhao, Haidong,Song, Xiaojie,et al. Self-assembly-induced near-infrared fluorescent nanoprobes for effective tumor molecular imaging[J]. journal of materials chemistry b,2014,2(32):5302-5308. |
| APA | Wu, Hao,Zhao, Haidong,Song, Xiaojie,Li, Shen,Ma, Xiaojun,&Tan, Mingqian.(2014).Self-assembly-induced near-infrared fluorescent nanoprobes for effective tumor molecular imaging.journal of materials chemistry b,2(32),5302-5308. |
| MLA | Wu, Hao,et al."Self-assembly-induced near-infrared fluorescent nanoprobes for effective tumor molecular imaging".journal of materials chemistry b 2.32(2014):5302-5308. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。