Gastroretentive drug delivery systems for the treatment of Helicobacter pylori
文献类型：期刊论文
| 作者 | Zhao, Shan1,2; Lv, Yan1,2; Zhang, Jian-Bin1,2; Wang, Bing1,2; Lv, Guo-Jun1; Ma, Xiao-Jun1 |
| 刊名 | world journal of gastroenterology
 |
| 出版日期 | 2014-07-28 |
| 卷号 | 20期号:28页码:9321-9329 |
| 关键词 | Helicobacter pylori Gastroretentive systems Floating systems Bioadhesive systems Expandable systems |
| 通讯作者 | 马小军 |
| 英文摘要 | helicobacter pylori (h. pylori) is one of the most common pathogenic bacterial infections and is found in the stomachs of approximately half of the world's population. it is the primary known cause of gastritis, gastroduodenal ulcer disease and gastric cancer. however, combined drug therapy as the general treatment in the clinic, the rise of antibiotic-resistant bacteria, adverse reactions and poor patient compliance are major obstacles to the eradication of h. pylori. oral site-specific drug delivery systems that could increase the longevity of the treatment agent at the target site might improve the therapeutic effect and avoid side effects. gastroretentive drug delivery systems potentially prolong the gastric retention time and controlled/sustained release of a drug, thereby increasing the concentration of the drug at the application site, potentially improving its bioavailability and reducing the necessary dosage. recommended gastroretentive drug delivery systems for enhancing local drug delivery include floating systems, bioadhesive systems and expandable systems. in this review, we summarize the important physiological parameters of the gastrointestinal tract that affect the gastric residence time. we then focus on various aspects useful in the development of gastroretentive drug delivery systems, including current trends and the progress of novel forms, especially with respect to their application for the treatment of h. pylori infections. (c) 2014 baishideng publishing group inc. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 学科主题 | 物理化学 |
| 类目[WOS] | gastroenterology & hepatology |
| 研究领域[WOS] | gastroenterology & hepatology |
| 关键词[WOS] | compressed collagen sponges ; in-vitro evaluation ; dosage forms ; gastric retention ; mucoadhesive microspheres ; sequential therapy ; nondisintegrating tablets ; antibiotic-resistance ; superporous hydrogels ; infection |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000339389800013 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/144520]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Liaoning Provin, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Shan,Lv, Yan,Zhang, Jian-Bin,et al. Gastroretentive drug delivery systems for the treatment of Helicobacter pylori[J]. world journal of gastroenterology,2014,20(28):9321-9329. |
| APA | Zhao, Shan,Lv, Yan,Zhang, Jian-Bin,Wang, Bing,Lv, Guo-Jun,&Ma, Xiao-Jun.(2014).Gastroretentive drug delivery systems for the treatment of Helicobacter pylori.world journal of gastroenterology,20(28),9321-9329. |
| MLA | Zhao, Shan,et al."Gastroretentive drug delivery systems for the treatment of Helicobacter pylori".world journal of gastroenterology 20.28(2014):9321-9329. |
入库方式： OAI收割
来源：大连化学物理研究所
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