Natural Anionic Polymer Acts as Highly Efficient Trypsin Inhibitor Based on an Electrostatic Interaction Mechanism
文献类型：期刊论文
| 作者 | Lv, Yan1,2; Zhang, Jianbin1,2; Song, Yizhe1,2; Wang, Bing1,2; Wang, Shujun1; Zhao, Shan1,2; Lv, Guojun1; Ma, Xiaojun1 |
| 刊名 | macromolecular rapid communications
 |
| 出版日期 | 2014-09-01 |
| 卷号 | 35期号:18页码:1606-1610 |
| 关键词 | alginate biological applications of polymers drug delivery systems insulin trypsin inhibitors |
| 通讯作者 | 吕国军 ; 马小军 |
| 英文摘要 | sodium alginate (sa), acting as a trypsin inhibitor by means of electrostatic interaction, is studied. the half-maximal inhibitory concentration (ic50 = 0.05 mu g ml(-1)) of this natural anionic polymer is about 400 times lower than that of commercial soybean trypsin inhibitor (sti). unlike the ca2+-deprivation mechanisms, its inhibition may be attributed to preventing the trypsin active site (tas) from accessing the macromolecular substrates instead of denaturing it. sa is an efficient, innocuous, and cost-effective inhibitory excipient that can be conveniently used in many peptide and protein dosage formulations. |
| WOS标题词 | science & technology ; physical sciences |
| 学科主题 | 物理化学 |
| 类目[WOS] | polymer science |
| 研究领域[WOS] | polymer science |
| 关键词[WOS] | oral insulin delivery ; in-vitro ; enzyme ; calcium ; microparticles ; nanoparticles ; degradation ; hydrogels ; peptides ; proteins |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000342620700007 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/144522]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lv, Yan,Zhang, Jianbin,Song, Yizhe,et al. Natural Anionic Polymer Acts as Highly Efficient Trypsin Inhibitor Based on an Electrostatic Interaction Mechanism[J]. macromolecular rapid communications,2014,35(18):1606-1610. |
| APA | Lv, Yan.,Zhang, Jianbin.,Song, Yizhe.,Wang, Bing.,Wang, Shujun.,...&Ma, Xiaojun.(2014).Natural Anionic Polymer Acts as Highly Efficient Trypsin Inhibitor Based on an Electrostatic Interaction Mechanism.macromolecular rapid communications,35(18),1606-1610. |
| MLA | Lv, Yan,et al."Natural Anionic Polymer Acts as Highly Efficient Trypsin Inhibitor Based on an Electrostatic Interaction Mechanism".macromolecular rapid communications 35.18(2014):1606-1610. |
入库方式： OAI收割
来源：大连化学物理研究所
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