Chitosan oligosaccharides block LPS-induced O-GlcNAcylation of NF-kappa B and endothelial inflammatory response
文献类型：期刊论文
| 作者 | Li, Yu1,2,3; Liu, Hongtao3; Xu, Qing-Song1; Du, Yu-Guang1; Xu, Jian3 |
| 刊名 | carbohydrate polymers
 |
| 出版日期 | 2014-01-02 |
| 卷号 | 99页码:568-578 |
| 关键词 | Chitosan oligosaccharides Lipopolysaccharides (LPS) Endothelial cells O-GlcNAcylation Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B) Inflammatory response |
| 英文摘要 | it is known that chitosan oligosaccharides (cos) suppress lps-induced vascular endothelial inflammatory response by mechanism involving nf-kappa b blockade. it remains unknown how cos inhibit nf-kappa b. we provided evidence both in cultured endothelial cells and mouse model supporting a new mechanism. regardless of the endothelial cell types, the lps-induced nf-kappa b-dependent inflammatory gene expression was suppressed by cos, which was associated with reduced nf-kappa b nucleus translocation. lps enhanced o-glcnac modification of nf-kappa b/p65 and activated nf-kappa b pathway, which could be prevented either by sirna knockdown of o-glcnac transferase (ogt) or pretreatment with cos. inhibition of either mitogen-activated protein kinase or superoxide generation abolishes lps-induced nf-kappa b o-glcnacylation. consistently, aortic tissues from lps-treated mice presented enhanced nf-kappa b/p65 o-glcnacylation in association with upregulated gene expression of inflammatory cytokines in vascular tissues; however, pre-administration of cos prevented these responses. in conclusion, cos decreased ogt-dependent o-glcnacylation of nf-kappa b and thereby attenuated lps-induced vascular endothelial inflammatory response. (c) 2013 elsevier ltd. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, applied ; chemistry, organic ; polymer science |
| 研究领域[WOS] | chemistry ; polymer science |
| 关键词[WOS] | in-vitro ; nucleocytoplasmic proteins ; glcnac modification ; insulin-resistance ; signaling pathway ; oxidative stress ; immune-system ; cells ; activation ; chitooligosaccharides |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000329256600073 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/145521]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Univ Oklahoma, Hlth Sci Ctr, Dept Med, Oklahoma City, OK 73104 USA |
| 推荐引用方式 GB/T 7714 | Li, Yu,Liu, Hongtao,Xu, Qing-Song,et al. Chitosan oligosaccharides block LPS-induced O-GlcNAcylation of NF-kappa B and endothelial inflammatory response[J]. carbohydrate polymers,2014,99:568-578. |
| APA | Li, Yu,Liu, Hongtao,Xu, Qing-Song,Du, Yu-Guang,&Xu, Jian.(2014).Chitosan oligosaccharides block LPS-induced O-GlcNAcylation of NF-kappa B and endothelial inflammatory response.carbohydrate polymers,99,568-578. |
| MLA | Li, Yu,et al."Chitosan oligosaccharides block LPS-induced O-GlcNAcylation of NF-kappa B and endothelial inflammatory response".carbohydrate polymers 99(2014):568-578. |
入库方式： OAI收割
来源：大连化学物理研究所
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