Serum Metabolomics Study of Polycystic Ovary Syndrome Based on Liquid Chromatography-Mass Spectrometry
文献类型：期刊论文
| 作者 | Zhao, Xinjie1; Xu, Fang2; Qi, Bing3; Hao, Songli2; Li, Yanjie1; Li, Yan2; Zou, Lihong4; Lu, Caixia2; Xu, Guowang1; Hou, Lihui2 |
| 刊名 | journal of proteome research
 |
| 出版日期 | 2014-02-01 |
| 卷号 | 13期号:2页码:1101-1111 |
| 关键词 | Metabolomics LC-MS polycystic ovary syndrome biomarkers |
| 英文摘要 | polycystic ovary syndrome (pcos) is a complex, heterogeneous disorder, which produces in 5-10% reproductive age women. in this study, a nontargeted metabolomics approach based on ultra high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry is used to investigate serum metabolic characteristics of pcos. pcos women and healthy control can be clustered into two distinct groups based on multivariate statistical analysis. significant increase in the levels of unsaturated free fatty acids, fatty acid amides, sulfated steroids, glycated amino acid and the decrease in levels of lysophosphatidylcholines, lysophosphatidylethanolamines, etc., were found. these metabolites showed abnormalities of lipid- and androgen-metabolism, increase of stearoyl-coa desaturase (scd) activity and accumulation of advanced glycation end-products in pcos patients. on the basis of the binary logistic regression model, free fatty acid (ffa) 18:1/ffa 18:0, ffa 20:3, dihydrotestosterone sulfate, glycated phenylalanine, and uridine were combined as a diagnostic biomarker. the area under the curve (auc) of combinational biomarker was 0.839 in 131 discovery phase samples and 0.874 in 109 validation phase samples. the findings of our study offer a new insight to understand the pathogenesis mechanism, and the discriminating metabolites may provide a prospect for pcos diagnosis. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | biochemical research methods |
| 研究领域[WOS] | biochemistry & molecular biology |
| 关键词[WOS] | stearoyl-coa desaturase ; glycation end-products ; free fatty-acids ; dehydroepiandrosterone-sulfate ; insulin-resistance ; chronic inflammation ; luteinizing-hormone ; oxidative stress ; syndrome pcos ; cancer-risk |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000331164100068 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/145531]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Heilongjiang Univ Chinese Med, Affiliated Hosp 1, Gynaecol Clin, Harbin 150040, Peoples R China 3.Beijing Univ Chinese Med, Subsidiary Dongfang Hosp, Beijing 100078, Peoples R China 4.Med Univ, Affiliated Hosp 1, Harbin 150001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Xinjie,Xu, Fang,Qi, Bing,et al. Serum Metabolomics Study of Polycystic Ovary Syndrome Based on Liquid Chromatography-Mass Spectrometry[J]. journal of proteome research,2014,13(2):1101-1111. |
| APA | Zhao, Xinjie.,Xu, Fang.,Qi, Bing.,Hao, Songli.,Li, Yanjie.,...&Hou, Lihui.(2014).Serum Metabolomics Study of Polycystic Ovary Syndrome Based on Liquid Chromatography-Mass Spectrometry.journal of proteome research,13(2),1101-1111. |
| MLA | Zhao, Xinjie,et al."Serum Metabolomics Study of Polycystic Ovary Syndrome Based on Liquid Chromatography-Mass Spectrometry".journal of proteome research 13.2(2014):1101-1111. |
入库方式： OAI收割
来源：大连化学物理研究所
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