Spatial blockage of ionic current for electrophoretic translocation of DNA through a graphene nanopore
文献类型：期刊论文
| 作者 | Lv, Wenping; Liu, Shengju; Li, Xin; Wu, Ren'an |
| 刊名 | electrophoresis
 |
| 出版日期 | 2014-04-01 |
| 卷号 | 35期号:8页码:1144-1151 |
| 关键词 | DNA sequencing Graphene nanopore Molecular dynamics simulation Noise of ionic current Translocation status of DNA |
| 英文摘要 | graphene nanopore has been promising the ultra-high resolution for dna sequencing due to the atomic thickness and excellent electronic properties of the graphene monolayer. the dynamical translocation phenomena and/or behaviors underneath the blocked ionic current, however, have not been well unveiled to date for the translocation of dna electrophoretically through a graphene nanopore. in this report, the assessment on the sensitivity of ionic current to instantaneous statuses of dna in a 2.4 nm graphene nanopore was carried out based on the all-atom molecular dynamics simulations. by filtering out the thermal noise of ionic current, the instantaneous conformational variations of dna in a graphene nanopore have been unveiled from the fluctuations of ionic current, because of the spatial blockage effect of dna against ionic current. interestingly, the neighborhood effect of dna against ionic current was also observed within a distance of 1.5 nm nearby the graphene nanopore, suggesting the further precise control for dna translocation through a graphene nanopore in gene sequencing. moreover, the sensitivity of the blocked ionic current toward the instantaneous conformations of dna in a graphene nanopore demonstrates the great potential of graphene nanopores in the dynamics analysis of single molecules. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | solid-state nanopores ; molecular-dynamics ; simulations ; challenges ; sensors |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000334126600009 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/145548]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lv, Wenping,Liu, Shengju,Li, Xin,et al. Spatial blockage of ionic current for electrophoretic translocation of DNA through a graphene nanopore[J]. electrophoresis,2014,35(8):1144-1151. |
| APA | Lv, Wenping,Liu, Shengju,Li, Xin,&Wu, Ren'an.(2014).Spatial blockage of ionic current for electrophoretic translocation of DNA through a graphene nanopore.electrophoresis,35(8),1144-1151. |
| MLA | Lv, Wenping,et al."Spatial blockage of ionic current for electrophoretic translocation of DNA through a graphene nanopore".electrophoresis 35.8(2014):1144-1151. |
入库方式： OAI收割
来源：大连化学物理研究所
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