Study of Induction Chemotherapy Efficacy in Oral Squamous Cell Carcinoma Using Pseudotargeted Metabolomics
文献类型：期刊论文
| 作者 | Ye, Guozhu1; Liu, Ying2; Yin, Peiyuan1; Zeng, Zhongda1; Huang, Qiang1; Kong, Hongwei1; Lu, Xin1; Zhong, Laiping2; Zhang, Zhiyuan2; Xu, Guowang1 |
| 刊名 | journal of proteome research
 |
| 出版日期 | 2014-04-01 |
| 卷号 | 13期号:4页码:1994-2004 |
| 关键词 | pseudotargeted metabolomics oral squamous cell carcinoma potential biomarkers induction chemotherapy metabolomics personalized medicine |
| 英文摘要 | the effect of induction chemotherapy on oral cancer is controversial owing to inconsistent results. however, the efficacy of induction chemotherapy is closely related to locoregional recurrence, distant metastasis, and overall survival after the treatment. a pseudotargeted metabolomics revealed that metabolites involved in glycolysis and amino acid metabolism were inversely regulated in patients with different before operation chemotherapy responses, and most fatty acids, steroids, and antioxidant substances were up-regulated in all patients after the treatment. among the metabolites, lactic acid, glucose, glutamic acid, aspartic acid, leucine, and glycerol were remarkably associated with induction chemotherapy efficacy. subsequently, lactic acid, glutamic acid, and aspartic acid were defined as potential biomarkers of the suitability and efficacy of induction chemotherapy. our results show that 100.0 and 84.37% of patients with different chemotherapy efficacy were correctly identified in the training and test sets, respectively. moreover, patient suitability for treatment was correctly predicted for 100.0, 81.25, and 100.0% of patients in the training, test, and external validation sets, respectively. in conclusion, metabolites related to glycolysis, redox homeostasis, and anabolic progress were indicative of induction chemotherapy efficacy both pre- and post-chemotherapy and beneficial for outcome evaluation and prediction. these results illustrate the potentials of metabolomics in personalized induction chemotherapy. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | biochemical research methods |
| 研究领域[WOS] | biochemistry & molecular biology |
| 关键词[WOS] | mass-spectrometry ; cross-validation ; breast-cancer ; stem-cells ; serum ; performance ; signatures ; biomarker ; selection ; trial |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000334016400020 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/145599]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Shanghai Jiao Tong Univ, Peoples Hosp 9, Dept Oral & Maxillofacial Head & Neck Oncol, Sch Med, Shanghai 200011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ye, Guozhu,Liu, Ying,Yin, Peiyuan,et al. Study of Induction Chemotherapy Efficacy in Oral Squamous Cell Carcinoma Using Pseudotargeted Metabolomics[J]. journal of proteome research,2014,13(4):1994-2004. |
| APA | Ye, Guozhu.,Liu, Ying.,Yin, Peiyuan.,Zeng, Zhongda.,Huang, Qiang.,...&Xu, Guowang.(2014).Study of Induction Chemotherapy Efficacy in Oral Squamous Cell Carcinoma Using Pseudotargeted Metabolomics.journal of proteome research,13(4),1994-2004. |
| MLA | Ye, Guozhu,et al."Study of Induction Chemotherapy Efficacy in Oral Squamous Cell Carcinoma Using Pseudotargeted Metabolomics".journal of proteome research 13.4(2014):1994-2004. |
入库方式： OAI收割
来源：大连化学物理研究所
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