Mulberroside a protects against ischemic impairment in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion
文献类型：期刊论文
| 作者 | Wang, Cai-Ping1; Zhang, Lu-Zhong1; Li, Gui-Cai1; Shi, Yun-wei1; Li, Jian-Long1; Zhang, Xiao-Chuan1; Wang, Zhi-Wei1,2; Ding, Fei1; Liang, Xin-Miao1,3 |
| 刊名 | journal of neuroscience research
 |
| 出版日期 | 2014-07-01 |
| 卷号 | 92期号:7页码:944-954 |
| 关键词 | apoptosis mulberroside A inflammation ischemia neuroprotection |
| 英文摘要 | mulberroside a is a natural polyhydroxylated stilbene compound present at relatively high abundance in the roots and twigs of morus alba l. it is known for its nephroprotective, hypoglycemic, and antidiabetic effects. because its metabolite, oxyresveratrol, possessed purported anti-inflammatory and neuroprotective effects, we proposed that mulberroside a may elicit neuroprotective effects that can be used in the treatment of brain ischemic injury. therefore, we decided to investigate the pharmacological properties of mulberroside a in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion (ogd/r), evaluating its ability to counteract the hypoxia-ischemia impairment. the results showed that mulberroside a elicited neuroprotective effects comparable to nimodipine. the mechanistic studies showed that mulberroside a decreased the expressions of tumor necrosis factor-alpha (tnf-alpha), interleukin (il)-1 beta, and il-6 and inhibited the activation of nalp3, caspase-1, and nuclear factor-kappa b and the phosphorylation of extracellular signal-regulated protein kinases, the c-jun n-terminal kinase, and p38, exhibiting anti-inflammatory antiapoptotic effects. our results also further demonstrate that the proinflammatory cytokines of il-1 beta, il-6, and tnf-alpha are promising targets for treatment of cerebral ischemic injury. although further investigation is required for its development, all of these findings led us to speculate that mulberroside a is a candidate for the treatment of ischemic stroke, which would act as a multifactorial neuroprotectant. (c) 2014 wiley periodicals, inc. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | neurosciences |
| 研究领域[WOS] | neurosciences & neurology |
| 关键词[WOS] | morus-alba l. ; focal cerebral-ischemia ; cell-death ; in-vitro ; brain-injury ; oxidative stress ; oxyresveratrol ; activation ; stroke ; pathways |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000335704400013 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/145642]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Nantong Univ, Jiangsu Key Lab Neuroregenerat, Nantong 226001, Peoples R China 2.Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92717 USA 3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Cai-Ping,Zhang, Lu-Zhong,Li, Gui-Cai,et al. Mulberroside a protects against ischemic impairment in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion[J]. journal of neuroscience research,2014,92(7):944-954. |
| APA | Wang, Cai-Ping.,Zhang, Lu-Zhong.,Li, Gui-Cai.,Shi, Yun-wei.,Li, Jian-Long.,...&Liang, Xin-Miao.(2014).Mulberroside a protects against ischemic impairment in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion.journal of neuroscience research,92(7),944-954. |
| MLA | Wang, Cai-Ping,et al."Mulberroside a protects against ischemic impairment in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion".journal of neuroscience research 92.7(2014):944-954. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。