Clinical and non-targeted metabolomic profiling of homozygous carriers of Transcription Factor 7-like 2 variant rs7903146
文献类型：期刊论文
| 作者 | Wagner, Robert1,2,3; Li, Jia4; Kenar, Erhan5,6; Kohlbacher, Oliver5,6; Machicao, Fausto1,2,3; Haering, Hans-Ulrich1,2,3; Fritsche, Andreas1,2,3; Xu, Guowang4; Lehmann, Rainer2,3,7 |
| 刊名 | scientific reports
 |
| 出版日期 | 2014-06-13 |
| 卷号 | 4 |
| 英文摘要 | an important role of the type 2 diabetes risk variant rs7903146 in tcf7l2 in metabolic actions of various tissues, in particular of the liver, has recently been demonstrated by functional animal studies. accordingly, the tt diabetes risk allele may lead to currently unknown alterations in human. our study revealed no differences in the kinetics of glucose, insulin, c-peptide and non-esterified fatty acids during an ogtt in homozygous participants from a german diabetes risk cohort (n = 1832) carrying either the rs7903146 cc (n = 15) or the tt (n = 15) genotype. however, beta-cell function was impaired for tt carriers. covering more than 4000 metabolite ions the plasma metabolome did not reveal any differences between genotypes. our study argues against a relevant impact of tcf7l2 rs7903146 on the systemic level in humans, but confirms the role in the pathogenesis of type 2 diabetes in humans as a mechanism impairing insulin secretion. |
| WOS标题词 | science & technology |
| 类目[WOS] | multidisciplinary sciences |
| 研究领域[WOS] | science & technology - other topics |
| 关键词[WOS] | diabetes risk genes ; insulin-secretion ; glucose-metabolism ; islet function ; tcf7l2 ; polymorphisms ; mechanisms ; prevention ; morphology ; impact |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000337340500002 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/145672]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Univ Hosp Tuebingen, Dept Internal Med 4, Div Endocrinol Diabetol Angiol & Nephrol, Tubingen, Germany 2.Univ Tubingen, Helmholtz Zentrum Munchen, Inst Diabet Res & Metabol Dis, Tubingen, Germany 3.German Ctr Diabet Res DZD, Tubingen, Germany 4.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China 5.Univ Tubingen, Quantitat Biol Ctr, Ctr Bioinformat, D-72076 Tubingen, Germany 6.Univ Tubingen, Dept Comp Sci, D-72076 Tubingen, Germany 7.Univ Hosp Tuebingen, Dept Internal Med, Div Clin Chem & Pathobiochem, Tubingen, Germany |
| 推荐引用方式 GB/T 7714 | Wagner, Robert,Li, Jia,Kenar, Erhan,et al. Clinical and non-targeted metabolomic profiling of homozygous carriers of Transcription Factor 7-like 2 variant rs7903146[J]. scientific reports,2014,4. |
| APA | Wagner, Robert.,Li, Jia.,Kenar, Erhan.,Kohlbacher, Oliver.,Machicao, Fausto.,...&Lehmann, Rainer.(2014).Clinical and non-targeted metabolomic profiling of homozygous carriers of Transcription Factor 7-like 2 variant rs7903146.scientific reports,4. |
| MLA | Wagner, Robert,et al."Clinical and non-targeted metabolomic profiling of homozygous carriers of Transcription Factor 7-like 2 variant rs7903146".scientific reports 4(2014). |
入库方式： OAI收割
来源：大连化学物理研究所
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