Enantioselective Synthesis of Highly Functionalized Dihydrofurans through Copper-Catalyzed Asymmetric Formal [3+2] Cycloaddition of beta-Ketoesters with Propargylic Esters
文献类型：期刊论文
| 作者 | Zhu, Fu-Lin1,2; Wang, Ya-Hui1; Zhang, De-Yang1,2; Xu, Jie1; Hu, Xiang-Ping1 |
| 刊名 | angewandte chemie-international edition
 |
| 出版日期 | 2014-09-15 |
| 卷号 | 53期号:38页码:10223-10227 |
| 关键词 | 2 asymmetric catalysis copper cycloadditions synthetic methods 3-dihydrofurans |
| 英文摘要 | an enantioselective synthesis of highly functionalized dihydrofurans through a copper-catalyzed asymmetric [3+2] cycloaddition of beta-ketoesters with propargylic esters has been developed. with a combination of cu(otf)(2) and a chiral tridentate p, n, n ligand as the catalyst, a variety of 2,3-dihydrofurans bearing an exocyclic double bond at the 2 position were obtained in good chemical yields and with good to high enantioselectivities. the exocyclic double bond can be hydrogenated in a highly diastereoselective fashion to give unusual cis-2,3-dihydrofuran derivatives, thus further enhancing the scope of this transformation. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, multidisciplinary |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | one-pot synthesis ; one-step cyclization ; 1,3-dicarbonyl compounds ; substituted dihydrofurans ; tetrasubstituted 2,3-dihydrofurans ; regioselective synthesis ; efficient synthesis ; radical synthesis ; tandem reaction ; ionic liquids |
| 收录类别 | SCI ; IC ; CCR |
| 语种 | 英语 |
| WOS记录号 | WOS:000342761700043 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/145866]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Fu-Lin,Wang, Ya-Hui,Zhang, De-Yang,et al. Enantioselective Synthesis of Highly Functionalized Dihydrofurans through Copper-Catalyzed Asymmetric Formal [3+2] Cycloaddition of beta-Ketoesters with Propargylic Esters[J]. angewandte chemie-international edition,2014,53(38):10223-10227. |
| APA | Zhu, Fu-Lin,Wang, Ya-Hui,Zhang, De-Yang,Xu, Jie,&Hu, Xiang-Ping.(2014).Enantioselective Synthesis of Highly Functionalized Dihydrofurans through Copper-Catalyzed Asymmetric Formal [3+2] Cycloaddition of beta-Ketoesters with Propargylic Esters.angewandte chemie-international edition,53(38),10223-10227. |
| MLA | Zhu, Fu-Lin,et al."Enantioselective Synthesis of Highly Functionalized Dihydrofurans through Copper-Catalyzed Asymmetric Formal [3+2] Cycloaddition of beta-Ketoesters with Propargylic Esters".angewandte chemie-international edition 53.38(2014):10223-10227. |
入库方式： OAI收割
来源：大连化学物理研究所
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