Novel chiral stationary phases based on peptoid combining a quinine/quinidine moiety through a C9-position carbamate group
文献类型：期刊论文
| 作者 | Wu, Haibo1; Wang, Dongqiang1; Song, Guangjun1; Ke, Yanxiong1; Liang, Xinmiao1,2 |
| 刊名 | journal of separation science
 |
| 出版日期 | 2014-04-01 |
| 卷号 | 37期号:8页码:934-943 |
| 关键词 | Chiral stationary phases Cinchona alkaloid Enantiomer separation Enantiorecognition Peptoids |
| 英文摘要 | by connecting a quinine or quinidine moiety to the peptoid chain through the c9-position carbamate group, we synthesized two new chiral selectors. after immobilizing them onto 3-mercaptopropyl-modified silica gel, two novel chiral stationary phases were prepared. with neutral, acid, and basic chiral compounds as analytes, we evaluated these two stationary phases and compared their chromatographic performance with chiral columns based on quinine tert-butyl carbamate and the previous peptoid. from the resolution of neutral and basic analytes under normal-phase mode, it was found that the new stationary phases exhibited much better enantioselectivity than the quinine tert-butyl carbamate column; the peptoid moiety played an important role in enantiorecognition, which controlled the elution orders of enantiomers; the assisting role of the cinchona alkaloid moieties was observed in some separations. under acid polar organic phase mode, it was proved that cinchona alkaloid moieties introduced excellent enantiorecognitions for chiral acid compounds; in some separations, the peptoid moiety affected enantioseparations as well. overall, chiral moieties with specific enantioselectivity were demonstrated to improve the performance of peptoid chiral stationary phase efficiently. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, analytical |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | cinchona alkaloids ; anion-exchangers ; amino-acids ; liquid-chromatography ; quinine ; enantioselectivity ; separations ; derivatives ; resolution ; recognition |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000334059900006 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/145868]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.E China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Sch Pharm, Minist Educ, Shanghai 200237, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Haibo,Wang, Dongqiang,Song, Guangjun,et al. Novel chiral stationary phases based on peptoid combining a quinine/quinidine moiety through a C9-position carbamate group[J]. journal of separation science,2014,37(8):934-943. |
| APA | Wu, Haibo,Wang, Dongqiang,Song, Guangjun,Ke, Yanxiong,&Liang, Xinmiao.(2014).Novel chiral stationary phases based on peptoid combining a quinine/quinidine moiety through a C9-position carbamate group.journal of separation science,37(8),934-943. |
| MLA | Wu, Haibo,et al."Novel chiral stationary phases based on peptoid combining a quinine/quinidine moiety through a C9-position carbamate group".journal of separation science 37.8(2014):934-943. |
入库方式： OAI收割
来源：大连化学物理研究所
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