The Inhibition of the Components from Shengmai Injection towards UDP-Glucuronosyltransferase
文献类型：期刊论文
| 作者 | Jiang, Li-Peng1; Zhao, Jin2; Cao, Yun-Feng3; Hong, Mo4,5,6,7; Sun, Dong-Xue2; Sun, Xiao-Yu4,5,6,7; Yin, Jun2; Zhu, Zhi-Tu1; Fang, Zhong-Ze8 |
| 刊名 | evidence-based complementary and alternative medicine
 |
| 出版日期 | 2014 |
| 英文摘要 | themechanism of shengmai injection-(smi-) related drug-drug interaction remains unclear. evaluation of the inhibition potential of smi's ingredients towards udp-glucuronosyltransferases (ugts) activity will provide a new insight to understand smi-related drug-drug interaction. in vitro incubation system to model ugt reaction was used. recombinant ugt isoforms-catalyzed 4-methylumbelliferone (4-mu) glucuronidation and ugt1a4-catalyzed trifluoperazine (tfp) glucuronidation reactions were employed to phenotype the inhibition profile of maidong's components towards the activity of ugt isoforms. different inhibition potential of maidong's components towards various ugt isoforms was observed. based on the inhibition kinetic investigation results, ophiopogonin d (od) noncompetitively inhibited ugt1a6 and competitively inhibited ugt1a8, ophiopogonin d ' (od ') noncompetitively inhibited ugt1a6 and ugt1a10, and ruscorectal (ru) exhibited competitive inhibition towards ugt1a4. the inhibition kinetic parameters were calculated to be 20.6, 40.1, 5.3, 9.0, and 0.02 mu m, respectively. in combination with our previous results obtained for the inhibition of ugt isoforms by ginsenosides and wuweizi components, the important smi ingredients exhibiting strong inhibition towards ugt isoforms were highlighted. all the results obtained in the present study provide a new insight to understand smi-related drug-drug interaction. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | integrative & complementary medicine |
| 研究领域[WOS] | integrative & complementary medicine |
| 关键词[WOS] | glucuronidation ; androsterone ; receptor ; ugt |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000344665900001 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/145870]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Liaoning Med Univ, Affiliated Hosp 1, Jinzhou 121001, Liaoning, Peoples R China 2.Shenyang Pharmaceut Univ, Sch Tradit Chinese Med, Shenyang 110016, Peoples R China 3.Shanghai Inst Planned Parenthood Res, Key Lab Contracept & Devices Res NPFPC, Shanghai Engineer & Technol Res Ctr Reprod Hlth D, Shanghai 200032, Peoples R China 4.Chinese Acad Sci, Joint Ctr Translat Med, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 5.Liaoning Med Univ, Affiliated Hosp 1, Dalian 116023, Peoples R China 6.Chinese Acad Sci, Dalian Inst Chem Phys, Joint Ctr Translat Med, Dalian 116001, Peoples R China 7.Dalian Univ, Affiliated Zhongshan Hosp, Dalian 116001, Peoples R China 8.Tianjin Med Univ, Dept Toxicol, Sch Publ Hlth, Tianjin 300070, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Li-Peng,Zhao, Jin,Cao, Yun-Feng,et al. The Inhibition of the Components from Shengmai Injection towards UDP-Glucuronosyltransferase[J]. evidence-based complementary and alternative medicine,2014. |
| APA | Jiang, Li-Peng.,Zhao, Jin.,Cao, Yun-Feng.,Hong, Mo.,Sun, Dong-Xue.,...&Fang, Zhong-Ze.(2014).The Inhibition of the Components from Shengmai Injection towards UDP-Glucuronosyltransferase.evidence-based complementary and alternative medicine. |
| MLA | Jiang, Li-Peng,et al."The Inhibition of the Components from Shengmai Injection towards UDP-Glucuronosyltransferase".evidence-based complementary and alternative medicine (2014). |
入库方式： OAI收割
来源：大连化学物理研究所
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