Enzymatic preparation of kappa-carrageenan oligosaccharides and their anti-angiogenic activity
文献类型：期刊论文
| 作者 | Yao, Ziang1; Wu, Haige1,2; Zhang, Shengxia1; Du, Yuguang2 |
| 刊名 | carbohydrate polymers
 |
| 出版日期 | 2014-01-30 |
| 卷号 | 101页码:359-367 |
| 关键词 | kappa-Carrageenan oligosaccharides Anti-tumor Anti-angiogenesis CD 105 |
| 英文摘要 | the mixture of kappa-neocarrabiose-sulfate, kappa-neocarrahexaose-sulfate and kappa-neocarraoctaose-sulfate were prepared from kappa-carrageenan with enzyme. the anti-tumor and anti-angiogenic activity of obtained kappa-carrageenan oligosaccharides (kos), were explored. the results showed that kos could inhibit the proliferation, migration and tube formation of ecv304 cells, and could inhibit the growth of new vessels in cam model. kos displayed strong anti-tumor activity in both s180 and mcf-7 xenograft models. only human cd105 was detected in mcf-7 xenograft tumor, moreover kos could decrease the growing of new blood vessels derived from tumor cell. real-time pcr results showed that kos could suppress the mrna expression of human vegf, bfgf, bfgfr and cd105 in mcf-7 xenograft tumor. all these results indicated that kos has anti-tumor and anti-angiogenic activity in vivo and in vitro. especially k has the potency to inhibit the differentiation of tumor cell to blood vessel endothelial cell. (c) 2013 elsevier ltd. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, applied ; chemistry, organic ; polymer science |
| 研究领域[WOS] | chemistry ; polymer science |
| 关键词[WOS] | in-vitro ; anticoagulant activity ; inhibits angiogenesis ; vivo ; therapy ; growth ; cancer ; tumor ; gigartinales ; antitumor |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000330494800043 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/145912]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Dalian Univ, Sch Life Sci & Technol, Dalian 116622, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yao, Ziang,Wu, Haige,Zhang, Shengxia,et al. Enzymatic preparation of kappa-carrageenan oligosaccharides and their anti-angiogenic activity[J]. carbohydrate polymers,2014,101:359-367. |
| APA | Yao, Ziang,Wu, Haige,Zhang, Shengxia,&Du, Yuguang.(2014).Enzymatic preparation of kappa-carrageenan oligosaccharides and their anti-angiogenic activity.carbohydrate polymers,101,359-367. |
| MLA | Yao, Ziang,et al."Enzymatic preparation of kappa-carrageenan oligosaccharides and their anti-angiogenic activity".carbohydrate polymers 101(2014):359-367. |
入库方式： OAI收割
来源：大连化学物理研究所
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