In situ forming chitosan-based hydrogel as a lung sealant for biological lung volume reduction
文献类型：期刊论文
| 作者 | Songkroh, Titima1,2; Xie, Hongguo1; Yu, Weiting1; Lv, Guojun1; Liu, Xiudong3; Wang, Lin4; Sun, Guangwei1; Xu, Xiaoxi1; Ma, Xiaojun1 |
| 刊名 | science bulletin
 |
| 出版日期 | 2015 |
| 卷号 | 60期号:2页码:235-240 |
| 关键词 | Chitosan-based hydrogels Biological lung volume reduction Lung sealants Emphysema |
| 英文摘要 | biological lung volume reduction (blvr) using lung sealant has received more attention recently as a new non-surgical approach to emphysema treatment. many tissue sealants have been studied but only a few have been proposed for blvr. in this work, we prepared in situ forming chitosan-based hydrogels (csg) using covalent cross-linking of chitosan and genipin in the cooperation of ionic interaction between chitosan and sodium orthophosphate hydrate (na3po4 center dot 12h(2)o) and characterized by fourier transform infrared spectroscopy, scanning electron microscopy and rheological methods. csg showed short gelation time (8 min), high swelling ratio (> 100 %) and non-toxicity (3t3 mouse fibroblast cell viability > 80 %) under physiological conditions. the application of lung sealant for blvr was tested in a chinese dog and evaluated by chest computed tomography. after 3 weeks of the installation of csg in bronchopulmonary segment, the gel formation was detected at a localized region of bronchi and the local atelectasis occurred. our findings indicate that this chitosan-based hydrogel is a promising new candidate for use as a lung sealant for blvr. |
| WOS标题词 | science & technology |
| 类目[WOS] | multidisciplinary sciences |
| 研究领域[WOS] | science & technology - other topics |
| 关键词[WOS] | advanced emphysema ; tissue ; biomaterials ; delivery ; therapy ; gels |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000348927000009 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/145952]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Dalian Univ, Coll Environm & Chem Engn, Dalian 116622, Peoples R China 4.Dalian Univ, Affiliated Zhongshan Hosp, Dalian 116001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Songkroh, Titima,Xie, Hongguo,Yu, Weiting,et al. In situ forming chitosan-based hydrogel as a lung sealant for biological lung volume reduction[J]. science bulletin,2015,60(2):235-240. |
| APA | Songkroh, Titima.,Xie, Hongguo.,Yu, Weiting.,Lv, Guojun.,Liu, Xiudong.,...&Ma, Xiaojun.(2015).In situ forming chitosan-based hydrogel as a lung sealant for biological lung volume reduction.science bulletin,60(2),235-240. |
| MLA | Songkroh, Titima,et al."In situ forming chitosan-based hydrogel as a lung sealant for biological lung volume reduction".science bulletin 60.2(2015):235-240. |
入库方式： OAI收割
来源：大连化学物理研究所
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