Pharmacokinetics and tissue distribution of five bufadienolides from the Shexiang Baoxin pill following oral administration to mice
文献类型：期刊论文
| 作者 | Huang, Huimei1,2; Yang, Yongge3; Lv, Chao2; Chang, Wanlin2; Peng, Chengcheng4; Wang, Shuping1; Ge, Guangbo5; Han, Lin1; Zhang, Weidong1,2,3; Liu, Runhui1,2 |
| 刊名 | journal of ethnopharmacology
 |
| 出版日期 | 2015-02-23 |
| 卷号 | 161页码:175-185 |
| 关键词 | Bufadienolides Shexiang Baoxin Pill Pharmacokinetic Tissue distribution LC-ESI-MS/MS |
| 英文摘要 | ethnopharmacological relevance: shexiang baoxin pill (sbp) is a well-known composite formula of traditional chinese medicine (tcm), widely used to treat cardiovascular diseases such as angina pectoris and myocardial infarction. bufadienolides are major active compounds of venenum bufonis, which is one of the seven materiamedicas that comprise the shexiang baoxin pill. previous pharmacokinetics studies of bufadienolides have typically used a single medicinal material delivered to rats. in this study, we have chosen the mouse, a more proper animal model than the rat, to investigate the in vivo pharmacokinetics and tissue distribution of bufadienolides from the shexiang baoxin pill. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | plant sciences ; chemistry, medicinal ; integrative & complementary medicine ; pharmacology & pharmacy |
| 研究领域[WOS] | plant sciences ; pharmacology & pharmacy ; integrative & complementary medicine |
| 关键词[WOS] | tandem mass-spectrometry ; rat plasma ; toad venom ; chromatography ; extract ; hplc ; constituents ; ionization ; induction ; chansu |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000349731100022 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/145985]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China 2.Fujian Univ Tradit Chinese Med, Sch Pharm, Fuzhou 350108, Fujian, Peoples R China 3.Beijing Mil Command Gen Hosp, Dept Clin Pharmacol, Beijing 100700, Peoples R China 4.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China 5.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Huimei,Yang, Yongge,Lv, Chao,et al. Pharmacokinetics and tissue distribution of five bufadienolides from the Shexiang Baoxin pill following oral administration to mice[J]. journal of ethnopharmacology,2015,161:175-185. |
| APA | Huang, Huimei.,Yang, Yongge.,Lv, Chao.,Chang, Wanlin.,Peng, Chengcheng.,...&Liu, Runhui.(2015).Pharmacokinetics and tissue distribution of five bufadienolides from the Shexiang Baoxin pill following oral administration to mice.journal of ethnopharmacology,161,175-185. |
| MLA | Huang, Huimei,et al."Pharmacokinetics and tissue distribution of five bufadienolides from the Shexiang Baoxin pill following oral administration to mice".journal of ethnopharmacology 161(2015):175-185. |
入库方式： OAI收割
来源：大连化学物理研究所
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