Theoretical Studies on the Folding Mechanisms for Different DNA G-quadruplexes
文献类型：期刊论文
| 作者 | Wu, Xue1; Xu, Peijun2; Wang, Jinguang3; Xu, Yong4; Fu, Ting1; Zhao, Meixia2; Zhang, Depeng2; Liu, Jiahui2; Shen, Hujun1; Xiu, Zhilong5 |
| 刊名 | advance in structural bioinformatics
 |
| 出版日期 | 2015 |
| 卷号 | 827页码:123-141 |
| 关键词 | G-quadruplex Go-model Fold |
| 英文摘要 | the g-quadruplex dna formed by the stack of guanines in human telomere sequence is a promising anticancer target. in this study we used the energy landscape theory to elucidate the folding mechanisms for the thrombin aptamer, form 1 and form 3 g-quadruplexes. the three g-quadruplexes were simulated with all-atom go-model. results show that, the three g-quadruplexes fold through a two-state mechanism. in the initial stage of the folding process, the compact structures are formed. the g-quadruplexes need to form g-triplex structures on the basis of the compact structures before folding to the native states. the folding free energy barrier of form 3 g-quadruplex is higher than thrombin aptamer and form 1, which shows that the structure of form 3 g-quadruplex has more stability than the other two g-quadruplexes. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | mathematical & computational biology ; medical informatics |
| 研究领域[WOS] | mathematical & computational biology ; medical informatics |
| 关键词[WOS] | human telomeric dna ; k+ solution ; crystal-structure ; helix formation ; biology ; binding ; simulations ; frustration ; tetraplex ; pathways |
| 收录类别 | BSCI ; SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000350428600011 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/146027]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Mol Modeling & Design, State Key Lab Mol React Dynam, Dalian, Liaoning, Peoples R China 2.Liaoning Normal Univ, Sch Phys & Elect Technol, Dalian, Liaoning, Peoples R China 3.Dalian Med Univ, Affiliated Hosp 1, Dalian, Peoples R China 4.Guangzhou Inst Biomed & Hlth, Guangzhou, Guangdong, Peoples R China 5.Dalian Univ Technol, Sch Life Sci & Technol, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Xue,Xu, Peijun,Wang, Jinguang,et al. Theoretical Studies on the Folding Mechanisms for Different DNA G-quadruplexes[J]. advance in structural bioinformatics,2015,827:123-141. |
| APA | Wu, Xue.,Xu, Peijun.,Wang, Jinguang.,Xu, Yong.,Fu, Ting.,...&Dai, H.(2015).Theoretical Studies on the Folding Mechanisms for Different DNA G-quadruplexes.advance in structural bioinformatics,827,123-141. |
| MLA | Wu, Xue,et al."Theoretical Studies on the Folding Mechanisms for Different DNA G-quadruplexes".advance in structural bioinformatics 827(2015):123-141. |
入库方式： OAI收割
来源：大连化学物理研究所
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