Injectable In situ Forming Chitosan-Based Hydrogels For Curcumin Delivery
文献类型：期刊论文
| 作者 | Songkroh, Titima1,2; Xie, Hongguo1; Yu, Weiting1; Liu, Xiudong3; Sun, Guangwei1; Xu, Xiaoxi1; Ma, Xiaojun1 |
| 刊名 | macromolecular research
 |
| 出版日期 | 2015 |
| 卷号 | 23期号:1页码:53-59 |
| 关键词 | chitosan hydrogel curcumin drug delivery |
| 英文摘要 | in this paper, a series of injectable in situ forming chitosan-based hydrogels were prepared by chemical crosslinking of chitosan and genipin with the cooperation of ionic bonds between chitosan and sodium salts at room temperature. four hydrogels (a, b, c, and d) were obtained by mixing chitosan, genipin and a sodium salt of trisodium phosphate (na3po4 center dot 12h(2)o), sodium sulfate (na2so4), sodium sulfite (na2so3), or sodium bicarbonate (nah-co3) and examined for their characteristics, morphology, and rheological properties. their cell viability assays exhibited low toxicity and the localized in situ gel formation was detected after subcutaneous injections in rat. curcumin which possesses many pharmaceutical potentials but has low bioavailability, was chosen as a drug model. in vitro curcumin release profiles exhibit sustained release properties with initial burst release for all hydrogels with about 3 to 6 times higher cumulative release than other gel controls. the results of this study demonstrate that our hydrogels have a potential as local curcumin carriers. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | polymer science |
| 研究领域[WOS] | polymer science |
| 关键词[WOS] | drug-delivery ; biological-activities ; biomaterials ; design ; cancer ; gels ; nanoparticles ; systems ; genipin ; ph |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000350361900008 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/146043]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, DICP, Dalian 116023, Liaoning, Peoples R China 2.UCAS, Beijing 100049, Peoples R China 3.Dalian Univ, Coll Environm & Chem Engn, Dalian 116622, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Songkroh, Titima,Xie, Hongguo,Yu, Weiting,et al. Injectable In situ Forming Chitosan-Based Hydrogels For Curcumin Delivery[J]. macromolecular research,2015,23(1):53-59. |
| APA | Songkroh, Titima.,Xie, Hongguo.,Yu, Weiting.,Liu, Xiudong.,Sun, Guangwei.,...&Ma, Xiaojun.(2015).Injectable In situ Forming Chitosan-Based Hydrogels For Curcumin Delivery.macromolecular research,23(1),53-59. |
| MLA | Songkroh, Titima,et al."Injectable In situ Forming Chitosan-Based Hydrogels For Curcumin Delivery".macromolecular research 23.1(2015):53-59. |
入库方式： OAI收割
来源：大连化学物理研究所
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