A weighted relative difference accumulation algorithm for dynamic metabolomics data: long-term elevated bile acids are risk factors for hepatocellular carcinoma
文献类型：期刊论文
| 作者 | Zhang, Weijian1; Zhou, Lina2; Yin, Peiyuan2; Wang, Jinbing3; Lu, Xin2; Wang, Xiaomei1; Chen, Jianguo3; Lin, Xiaohui1; Xu, Guowang2 |
| 刊名 | scientific reports
 |
| 出版日期 | 2015-03-11 |
| 卷号 | 5 |
| 英文摘要 | dynamic metabolomics studies can provide a systematic view of the metabolic trajectory during disease development and drug treatment and reveal the nature of biological processes at metabolic level. to extract important information in a systematic time dimension rather than at isolated time points, a weighted method based on the means and variations along the time points was proposed and first applied to previously published rat model data. the method was subsequently extended and applied to prospective metabolomics data analysis of hepatocellular carcinoma (hcc). permutation was employed for noise filtering and false discovery rate (fdr) was used for parameter optimization during the feature selection. long-term elevated serum bile acids were identified as risk factors for hcc development. |
| WOS标题词 | science & technology |
| 类目[WOS] | multidisciplinary sciences |
| 研究领域[WOS] | science & technology - other topics |
| 关键词[WOS] | gene-expression data ; time-series data ; ursodeoxycholic acid ; mass-spectrometry ; down-regulation ; rat-liver ; discovery ; hepatocarcinogenesis ; pathogenesis ; homeostasis |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000351138000006 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/146049]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Dalian Univ Technol, Sch Comp Sci & Technol, Dalian, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China 3.Qidong Liver Canc Inst, Qidong 226200, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Weijian,Zhou, Lina,Yin, Peiyuan,et al. A weighted relative difference accumulation algorithm for dynamic metabolomics data: long-term elevated bile acids are risk factors for hepatocellular carcinoma[J]. scientific reports,2015,5. |
| APA | Zhang, Weijian.,Zhou, Lina.,Yin, Peiyuan.,Wang, Jinbing.,Lu, Xin.,...&Xu, Guowang.(2015).A weighted relative difference accumulation algorithm for dynamic metabolomics data: long-term elevated bile acids are risk factors for hepatocellular carcinoma.scientific reports,5. |
| MLA | Zhang, Weijian,et al."A weighted relative difference accumulation algorithm for dynamic metabolomics data: long-term elevated bile acids are risk factors for hepatocellular carcinoma".scientific reports 5(2015). |
入库方式： OAI收割
来源：大连化学物理研究所
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