Regulating cell behaviors on micropillar topographies affected by interfacial energy
文献类型：期刊论文
| 作者 | Gao, Xinghua1; Chau, Yeung Yeung2; Xie, Jiao5; Wan, Jun1,6; Ren, Yanxiao4; Qin, Jianhua3; Wen, Weijia1,2,4,5 |
| 刊名 | rsc advances
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:29页码:22916-22922 |
| 英文摘要 | micro/ sub-micro substrate topography plays an important role in cell morphology and function. by localizing individual hepatic stellate cells on different micropillar topographies, we found that the cell morphology was thus greatly influenced due to the cell location. as a simple physical model showed, the morphological response of cells to micropillar topography can be triggered by a minimum interfacial energy. in particular, an established topography with a spacing of 2.5 mu m and pillar diameter of 5 mu m was found to be able to change the expression of e-cadherin and alpha-smooth muscle actin. it suggested that the size of the established topography might be closely related to cell epithelial-mesenchymal transition. this study has potential significance in mimicking the size of disse's space in pathological conditions and advanced the understanding of the physical mechanisms of liver fibrosis and cirrhosis. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, multidisciplinary |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | mesenchymal stem-cells ; differential regulation ; stiffness ; surfaces ; adhesion ; lineage ; size ; organization ; orientation ; platforms |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000350643700074 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/146065]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Hong Kong Univ Sci & Technol, Shenzhen Peking Univ, Med Ctr, Biomed Res Inst, Shenzhen, Peoples R China 2.Hong Kong Univ Sci & Technol, Dept Phys, Kowloon, Hong Kong, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China 4.Hong Kong Univ Sci & Technol, Shenzhen Res Inst, Shenzhen, Peoples R China 5.Chongqing Univ, Coll Phys, Soft Matter & Interdisciplinary Res Inst, Chongqing 630044, Peoples R China 6.Hong Kong Univ Sci & Technol, Div Iife Sci, Kowloon, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Xinghua,Chau, Yeung Yeung,Xie, Jiao,et al. Regulating cell behaviors on micropillar topographies affected by interfacial energy[J]. rsc advances,2015,5(29):22916-22922. |
| APA | Gao, Xinghua.,Chau, Yeung Yeung.,Xie, Jiao.,Wan, Jun.,Ren, Yanxiao.,...&Wen, Weijia.(2015).Regulating cell behaviors on micropillar topographies affected by interfacial energy.rsc advances,5(29),22916-22922. |
| MLA | Gao, Xinghua,et al."Regulating cell behaviors on micropillar topographies affected by interfacial energy".rsc advances 5.29(2015):22916-22922. |
入库方式： OAI收割
来源：大连化学物理研究所
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