Dopant titrating ion mobility spectrometry for trace exhaled nitric oxide detection
文献类型：期刊论文
| 作者 | Peng, Liying1,3; Hua, Lei1; Li, Enyou2; Wang, Weiguo1; Zhou, Qinghua1,3; Wang, Xin1; Wang, Changsong2; Li, Jinghua1; Li, Haiyang1 |
| 刊名 | journal of breath research
 |
| 出版日期 | 2015-03-01 |
| 卷号 | 9期号:1 |
| 关键词 | ion mobility spectrometry exhaled nitric oxide breath gas dopant |
| 英文摘要 | ion mobility spectrometry (ims) is a promising non-invasive tool for the analysis of exhaled gas and exhaled nitric oxide (no), a biomarker for diagnosis of respiratory diseases. however, the high moisture in exhaled gas always brings about extra overlapping ion peaks and results in poor identification ability. in this paper, p-benzoquinone (pbq) was introduced into ims to eliminate the interference of overlapping ion peaks and realize the selective identification of no. the overlapping ions caused by moisture were titrated by pbq and then converted to hydrated pbq anions (c6h4o2-(h2o)(n)). the no concentration could be determined by quantifying gas phase hydrated nitrite anions (no2-(h2o)(n)), product ions of no. under optimized conditions, a limit of detection (lod) of about 1.4 ppbv and a linear range of 10-200 ppbv were obtained for no even in 100% relative humidity (rh) purified air. furthermore, this established method was applied to measure hourly the exhaled no of eight healthy volunteers, and real-time monitoring the exhaled no of an esophageal carcinoma patient during radical surgery. these results revealed the potential of the current dopant titrating ims method in the measurement of exhaled no for medical disease diagnosis. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | biochemical research methods ; respiratory system |
| 研究领域[WOS] | biochemistry & molecular biology ; respiratory system |
| 关键词[WOS] | mass-spectrometry ; corona discharge ; breath ; air ; mixtures ; series ; gases ; media ; ims |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000351955400004 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/146117]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Harbin Med Univ, Dept Anesthesiol, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Liying,Hua, Lei,Li, Enyou,et al. Dopant titrating ion mobility spectrometry for trace exhaled nitric oxide detection[J]. journal of breath research,2015,9(1). |
| APA | Peng, Liying.,Hua, Lei.,Li, Enyou.,Wang, Weiguo.,Zhou, Qinghua.,...&Li, Haiyang.(2015).Dopant titrating ion mobility spectrometry for trace exhaled nitric oxide detection.journal of breath research,9(1). |
| MLA | Peng, Liying,et al."Dopant titrating ion mobility spectrometry for trace exhaled nitric oxide detection".journal of breath research 9.1(2015). |
入库方式： OAI收割
来源：大连化学物理研究所
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