Ginsenoside Rg1 Downregulates the Shear Stress Induced MCP-1 Expression by Inhibiting MAPK Signaling Pathway
文献类型：期刊论文
| 作者 | He, Jian1,2,3,4; Li, Yu-Lin4 |
| 刊名 | american journal of chinese medicine
 |
| 出版日期 | 2015 |
| 卷号 | 43期号:2页码:305-317 |
| 关键词 | HUVECs Mechanical Force (Shear Stress) Ginsenoside Rg1 MCP-1 MAP Kinase |
| 英文摘要 | ginsenoside rg1 has been reported to possess anti-inflammatory activities, but the effects of rg1 on the shear induced mcp-1 upregulation mechanism on endothelial cells (ecs) remain to be determined. in this study, we show that rg1 down modulates shear induced pro-inflammatory cytokine mcp-1 gene expression and monocytes adhesion without potential cell toxicity. the negative effects on monocytes adhesion is due to a decrease in mcp-1 protein release. furthermore, the inhibitory effect of rg1 on the phosphorylation level of erk, p38, and jnk mitogen-activated protein kinase (mapk) induced by shear stress (ss) is similar with that of specific chemical inhibitors for mapk pathways activation. these results demonstrate that ginsenoside rg1 inhibits the shear induced inflammation by suppressing the mapk pathway. this suggests that rg1 may serve as a novel anti-inflammatory agent for inflammation-induced cardiovascular diseases treatment. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | integrative & complementary medicine ; medicine, general & internal |
| 研究领域[WOS] | integrative & complementary medicine ; general & internal medicine |
| 关键词[WOS] | monocyte chemoattractant protein-1 ; vascular endothelial-cells ; gene-expression ; glucocorticoid-receptor ; chemotactic protein-1 ; in-vitro ; mechanotransduction ; increases ; kinases ; growth |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000353162200008 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/146163]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China 2.Univ Calif San Diego, Dept Bioengn, San Diego, CA 92037 USA 3.Univ Calif San Diego, Inst Engn Med, San Diego, CA 92037 USA 4.Jilin Univ, Minist Educ, Norman Bethune Coll Med, Key Lab Pathobiol, Changchun 130021, Jilin, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Jian,Li, Yu-Lin. Ginsenoside Rg1 Downregulates the Shear Stress Induced MCP-1 Expression by Inhibiting MAPK Signaling Pathway[J]. american journal of chinese medicine,2015,43(2):305-317. |
| APA | He, Jian,&Li, Yu-Lin.(2015).Ginsenoside Rg1 Downregulates the Shear Stress Induced MCP-1 Expression by Inhibiting MAPK Signaling Pathway.american journal of chinese medicine,43(2),305-317. |
| MLA | He, Jian,et al."Ginsenoside Rg1 Downregulates the Shear Stress Induced MCP-1 Expression by Inhibiting MAPK Signaling Pathway".american journal of chinese medicine 43.2(2015):305-317. |
入库方式： OAI收割
来源：大连化学物理研究所
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