Alginate-calcium microsphere loaded with thrombin: A new composite biomaterial for hemostatic embolization
文献类型：期刊论文
| 作者 | Rong, Jing-jing1; Liang, Ming2; Xuan, Feng-qi2; Sun, Jing-yang2; Zhao, Li-jun2; Zhen, Hui-zhen3; Tian, Xiao-xiang2; Liu, Dan1,2; Zhang, Quan-yu1,2; Peng, Cheng-fei2 |
| 刊名 | international journal of biological macromolecules
 |
| 出版日期 | 2015-04-01 |
| 卷号 | 75页码:479-488 |
| 关键词 | Alginate Thrombin Microsphere Trauma Arterial embolization Hemostasis |
| 英文摘要 | to date, transcatheter arterial embolization (tae) has become a standard treatment to control intracavitary bleeding as an alternative to surgery. due to excellent biocompatibility and no residual in vivo, biodegradable materials are preferred in tae. however, gelfoam is the only commercially available biodegradable embolic material used to treat blunt trauma of solid abdominal viscera until now, and controversial on its stability and reliability never stopped in the past five decades. in this study, a new biodegradable macromolecule material (thrombin-loaded alginate-calcium microspheres, tacms) was prepared using electrostatic droplet techniques and a special method was developed for hemostatic embolization. thrombin was successfully loaded into microspheres with high encapsulation efficiency and drug loading capacity. a burst release of tacms was observed at early stage and sustained release later on, with the activity of thrombin preserved well. the strength of tacms mixed thrombus, which was used as embolic agent, increased in a dose-dependent manner after tacms were added. in addition, the tacms were verified to be of no cytotoxicity and systemic toxicity, and biodegradable in vivo. finally, the results of preliminary applications revealed that the tacms could serve as an effective and promising embolic material for blunt trauma and hemorrhage of solid abdominal viscera. (c) 2015 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | biochemistry & molecular biology |
| 研究领域[WOS] | biochemistry & molecular biology |
| 关键词[WOS] | splenic artery embolization ; controlled-release ; postpartum hemorrhage ; delivery-system ; in-vivo ; injury ; chitosan ; trauma ; biocompatibility ; complications |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000352332700063 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/146177]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Third Mil Med Univ, Chongqing 400038, Peoples R China 2.Shenyang Mil Reg, Dept Cardiol, Gen Hosp, Shenyang 110016, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Rong, Jing-jing,Liang, Ming,Xuan, Feng-qi,et al. Alginate-calcium microsphere loaded with thrombin: A new composite biomaterial for hemostatic embolization[J]. international journal of biological macromolecules,2015,75:479-488. |
| APA | Rong, Jing-jing.,Liang, Ming.,Xuan, Feng-qi.,Sun, Jing-yang.,Zhao, Li-jun.,...&Yu, Wei-ting.(2015).Alginate-calcium microsphere loaded with thrombin: A new composite biomaterial for hemostatic embolization.international journal of biological macromolecules,75,479-488. |
| MLA | Rong, Jing-jing,et al."Alginate-calcium microsphere loaded with thrombin: A new composite biomaterial for hemostatic embolization".international journal of biological macromolecules 75(2015):479-488. |
入库方式： OAI收割
来源：大连化学物理研究所
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