Flexible Fabrication of Shape-Controlled Collagen Building Blocks for Self-Assembly of 3D Microtissues
文献类型：期刊论文
| 作者 | Zhang, Xu1; Meng, Zhaoxu1; Ma, Jingyun1; Shi, Yang1; Xu, Hui1,2; Lykkemark, Simon1,3; Qin, Jianhua1 |
| 刊名 | small
 |
| 出版日期 | 2015-08-12 |
| 卷号 | 11期号:30页码:3666-3675 |
| 关键词 | building block collagen microdevices microtissues self assembly |
| 英文摘要 | creating artificial tissue-like structures that possess the functionality, specificity, and architecture of native tissues remains a big challenge. a new and straightforward strategy for generating shape-controlled collagen building blocks with a well-defined architecture is presented, which can be used for self-assembly of complex 3d microtissues. collagen blocks with tunable geometries are controllably produced and released via a membrane-templated microdevice. the formation of functional microtissues by embedding tissue-specific cells into collagen blocks with expression of specific proteins is described. the spontaneous self-assembly of cell-laden collagen blocks into organized tissue constructs with predetermined configurations is demonstrated, which are largely driven by the synergistic effects of cell-cell and cell-matrix interactions. this new strategy would open up new avenues for the study of tissue/organ morphogenesis, and tissue engineering applications. |
| WOS标题词 | science & technology ; physical sciences ; technology |
| 类目[WOS] | chemistry, multidisciplinary ; chemistry, physical ; nanoscience & nanotechnology ; materials science, multidisciplinary ; physics, applied ; physics, condensed matter |
| 研究领域[WOS] | chemistry ; science & technology - other topics ; materials science ; physics |
| 关键词[WOS] | cell-laden microgels ; hydrogels ; tissues ; biomaterials ; organization ; microfibers ; constructs ; scaffolds |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000359307700012 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/146435]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Aarhus Univ, Dept Clin Med, DK-8000 Aarhus C, Denmark |
| 推荐引用方式 GB/T 7714 | Zhang, Xu,Meng, Zhaoxu,Ma, Jingyun,et al. Flexible Fabrication of Shape-Controlled Collagen Building Blocks for Self-Assembly of 3D Microtissues[J]. small,2015,11(30):3666-3675. |
| APA | Zhang, Xu.,Meng, Zhaoxu.,Ma, Jingyun.,Shi, Yang.,Xu, Hui.,...&Qin, Jianhua.(2015).Flexible Fabrication of Shape-Controlled Collagen Building Blocks for Self-Assembly of 3D Microtissues.small,11(30),3666-3675. |
| MLA | Zhang, Xu,et al."Flexible Fabrication of Shape-Controlled Collagen Building Blocks for Self-Assembly of 3D Microtissues".small 11.30(2015):3666-3675. |
入库方式： OAI收割
来源：大连化学物理研究所
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