Rhodium-Catalyzed CH Annulation of Nitrones with Alkynes: A Regiospecific Route to Unsymmetrical 2,3-Diaryl-Substituted Indoles
文献类型：期刊论文
| 作者 | Yan, Hao; Wang, Haolong; Li, Xincheng; Xin, Xiaoyi; Wang, Chunxiang; Wan, Boshun |
| 刊名 | angewandte chemie-international edition
 |
| 出版日期 | 2015-09-01 |
| 卷号 | 54期号:36页码:10613-10617 |
| 关键词 | alkynes CH activation indoles nitrones rhodium |
| 英文摘要 | the direct ch annulation of anilines or related compounds with internal alkynes provides straightforward access to 2,3-disubstituted indole products. however, this transformation proceeds with poor regioselectivity in the synthesis of unsymmetrically 2,3-diaryl substituted indoles. herein, we report the rhodium(iii)-catalyzed ch annulation of nitrones with symmetrical diaryl alkynes as an alternative method to prepare 2,3-diaryl-substituted n-unprotected indoles with two different aryl groups. one of the aryl substituents is derived from nc-aryl ring of the nitrone and the other from the alkyne substrate, thus providing the indole products with exclusive regioselectivity. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, multidisciplinary |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | carbon triple bond ; n-aryl enamines ; nonrearranged monoterpenoid unit ; 3,4-fused tricyclic indoles ; 2,3-disubstituted indoles ; h activation ; efficient synthesis ; internal alkynes ; oxidative cyclization ; molecular-oxygen |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000360312800040 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/146494]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, Hao,Wang, Haolong,Li, Xincheng,et al. Rhodium-Catalyzed CH Annulation of Nitrones with Alkynes: A Regiospecific Route to Unsymmetrical 2,3-Diaryl-Substituted Indoles[J]. angewandte chemie-international edition,2015,54(36):10613-10617. |
| APA | Yan, Hao,Wang, Haolong,Li, Xincheng,Xin, Xiaoyi,Wang, Chunxiang,&Wan, Boshun.(2015).Rhodium-Catalyzed CH Annulation of Nitrones with Alkynes: A Regiospecific Route to Unsymmetrical 2,3-Diaryl-Substituted Indoles.angewandte chemie-international edition,54(36),10613-10617. |
| MLA | Yan, Hao,et al."Rhodium-Catalyzed CH Annulation of Nitrones with Alkynes: A Regiospecific Route to Unsymmetrical 2,3-Diaryl-Substituted Indoles".angewandte chemie-international edition 54.36(2015):10613-10617. |
入库方式： OAI收割
来源：大连化学物理研究所
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