Liposomal nanohybrid cerasomes for mitochondria-targeted drug delivery
文献类型：期刊论文
| 作者 | Wang, Yanfang1,2; Wang, Beibei1,2; Liao, Han1,2; Song, Xiaojie1,2; Wu, Hao1,2; Wang, Huihui1,2; Shen, Hujun3; Ma, Xiaojun1; Tan, Mingqian1,4 |
| 刊名 | journal of materials chemistry b
 |
| 出版日期 | 2015 |
| 卷号 | 3期号:36页码:7291-7299 |
| 英文摘要 | mitochondrial dysfunctions cause numerous human disorders and the development of mitochondria-targeted nanocarriers for drug delivery has aroused great attention. herein, we report the synthesis of a liposomal nanohybrid cerasome modified with triphosphonium (tpp) for drug delivery to the mitochondrial matrix. the cerasomes were observed to possess an average size of about 38 nm in diameter, and the theoretical simulation of gbemp mapping demonstrated that the amphiphilic organotrialkoxysilanes were stable as a bilayer equilibrium conformation after self-assembly. the cerasomes showed good stability, excellent biocompatibility and sustainable drug release behavior. moreover, the tpp-targeted cerasomes resulted in greater drug accumulation in mitochondria, thus leading to a greater antitumor effect as compared to non-targeted cerasomes by using doxorubicin as a modal drug. the specific accumulation of tpp-targeted cerasomes within mitochondria was also confirmed by using jc-1 as the fluorescent probe to analyze the mitochondrial transmembrane potential change. |
| WOS标题词 | science & technology ; technology |
| 类目[WOS] | materials science, biomaterials |
| 研究领域[WOS] | materials science |
| 关键词[WOS] | coarse-grained model ; electric multipole potentials ; molecular-dynamics ; gay-berne ; oxidative stress ; simulations ; doxorubicin ; release ; liquids ; nanoparticles |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000360658000016 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/146504]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Mol React Dynam, Dalian 116023, Peoples R China 4.Dalian Polytech Univ, Sch Food Sci & Technol, Dalian 116034, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yanfang,Wang, Beibei,Liao, Han,et al. Liposomal nanohybrid cerasomes for mitochondria-targeted drug delivery[J]. journal of materials chemistry b,2015,3(36):7291-7299. |
| APA | Wang, Yanfang.,Wang, Beibei.,Liao, Han.,Song, Xiaojie.,Wu, Hao.,...&Tan, Mingqian.(2015).Liposomal nanohybrid cerasomes for mitochondria-targeted drug delivery.journal of materials chemistry b,3(36),7291-7299. |
| MLA | Wang, Yanfang,et al."Liposomal nanohybrid cerasomes for mitochondria-targeted drug delivery".journal of materials chemistry b 3.36(2015):7291-7299. |
入库方式： OAI收割
来源：大连化学物理研究所
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