Inhibitory Effects of Highly Oxygenated Lanostane Derivatives from the Fungus Ganoderma lucidum on P-Glycoprotein and alpha-Glucosidase
文献类型：期刊论文
| 作者 | Zhao, Xi-Run1; Huo, Xiao-Kui1; Dong, Pei-Pei2,3; Wang, Chao1; Huang, Shan-Shan1; Zhang, Bao-Jing1; Zhang, Hou-Li1; Deng, Sa1; Liu, Ke-Xin1; Ma, Xiao-Chi1,2 |
| 刊名 | journal of natural products
 |
| 出版日期 | 2015-08-01 |
| 卷号 | 78期号:8页码:1868-1876 |
| 英文摘要 | twelve new highly oxygenated lanostane triterpenoids and nine known ganoderic acids were isolated from the fruiting body of ganoderma lucidum. the new compounds were lanostane nortriterpenoids with 27 carbons (1-5 and 8), lanostane nor-triterpenoids with 25 carbons (6 and 7), and lanostane triterpenoids (9-12) based on multiple spectroscopic data analysis, including hresims, 1d-nmr, 2d-nmr, and cd. compounds 1-5 were identified as rare nor-lanostanoids that contain a 17 beta-pentatomic lactone ring. compound 13, possessing a lactone ring, had been isolated previously. the p-glycoprotein (p-gp) inhibitory effects of compounds 1-21 were evaluated at a concentration of 20 mu m using an adriamycin (adm)-resistant human breast adenocarcinoma cell line (mcf-7/adr). compounds 1, 5, 18, and 20 and verapamil increased the accumulation of adm in mcf-7/adr cells approximately 3-fold when compared with the negative control. these data support the significant p-glycoprotein inhibitory activities of compounds 1, 5, 18, and 20. in silico docking analysis suggested these compounds had similar p-gp recognition mechanisms compared with those of verapamil (a classical inhibitor). furthermore, in an in vitro bioassay, compounds 2, 4, 5, 6, and 18 showed moderate inhibitory effects against alpha-glucosidase compared with those of the positive control acarbose. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | plant sciences ; chemistry, medicinal ; pharmacology & pharmacy |
| 研究领域[WOS] | plant sciences ; pharmacology & pharmacy |
| 关键词[WOS] | fruiting bodies ; fr karst ; intestinal-absorption ; c-30 terpenoids ; bitter c-27 ; in-vitro ; acid-f ; triterpenoids ; cells ; polysaccharides |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000360773700009 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/146511]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Dalian Med Univ, Coll Pharm, Key Lab Metab & Transport Liaoning, Dalian 116044, Peoples R China 2.Dalian Med Univ, Acad Integrat Med, Dalian 116044, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Xi-Run,Huo, Xiao-Kui,Dong, Pei-Pei,et al. Inhibitory Effects of Highly Oxygenated Lanostane Derivatives from the Fungus Ganoderma lucidum on P-Glycoprotein and alpha-Glucosidase[J]. journal of natural products,2015,78(8):1868-1876. |
| APA | Zhao, Xi-Run.,Huo, Xiao-Kui.,Dong, Pei-Pei.,Wang, Chao.,Huang, Shan-Shan.,...&Ma, Xiao-Chi.(2015).Inhibitory Effects of Highly Oxygenated Lanostane Derivatives from the Fungus Ganoderma lucidum on P-Glycoprotein and alpha-Glucosidase.journal of natural products,78(8),1868-1876. |
| MLA | Zhao, Xi-Run,et al."Inhibitory Effects of Highly Oxygenated Lanostane Derivatives from the Fungus Ganoderma lucidum on P-Glycoprotein and alpha-Glucosidase".journal of natural products 78.8(2015):1868-1876. |
入库方式： OAI收割
来源：大连化学物理研究所
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