Copper-Catalyzed Asymmetric Formal [3+2] Cycloaddition of Propargylic Acetates with Hydrazines: Enantioselective Synthesis of Optically Active 2-Pyrazolines
文献类型：期刊论文
| 作者 | Zhang, De-Yang1,2; Shao, Long1,2; Xu, Jie1; Hu, Xiang-Ping1 |
| 刊名 | acs catalysis
 |
| 出版日期 | 2015-09-01 |
| 卷号 | 5期号:9页码:5026-5030 |
| 关键词 | asymmetric catalysis copper cycloaddition propargylic ester 2-pyrazoline |
| 英文摘要 | a catalytic asymmetric [3 + 2] cycloaddition of hydrazines to bis-electrophilic c3 synthons generated from propargylic acetates, followed by an intramolecular 1,3-h migration, for the regio- and enantioselective construction of chiral 2-pyrazolines has been reported. by employment of copper catalysis in combination with a structurally rigid tridentate p,n,n-ligand, a variety of chiral 2-pyrazolines were obtained in good yields and with high enantioselectivities (up to 96% ee). a possible transition state has been proposed to explain the origin of the regio- and enantioselectivities. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, physical |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | azomethine imines ; 1,3-dipolar cycloaddition ; nitrile imines ; substitution-reactions ; 1,3-dicarbonyl compounds ; beta-ketoesters ; lewis-acid ; amination ; esters ; derivatives |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000361089700008 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/146529]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, De-Yang,Shao, Long,Xu, Jie,et al. Copper-Catalyzed Asymmetric Formal [3+2] Cycloaddition of Propargylic Acetates with Hydrazines: Enantioselective Synthesis of Optically Active 2-Pyrazolines[J]. acs catalysis,2015,5(9):5026-5030. |
| APA | Zhang, De-Yang,Shao, Long,Xu, Jie,&Hu, Xiang-Ping.(2015).Copper-Catalyzed Asymmetric Formal [3+2] Cycloaddition of Propargylic Acetates with Hydrazines: Enantioselective Synthesis of Optically Active 2-Pyrazolines.acs catalysis,5(9),5026-5030. |
| MLA | Zhang, De-Yang,et al."Copper-Catalyzed Asymmetric Formal [3+2] Cycloaddition of Propargylic Acetates with Hydrazines: Enantioselective Synthesis of Optically Active 2-Pyrazolines".acs catalysis 5.9(2015):5026-5030. |
入库方式： OAI收割
来源：大连化学物理研究所
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