Neuroprotective effect of bisabolangelone on hydrogen peroxide-induced neurotoxicity in SH-SY5Y cells
文献类型：期刊论文
| 作者 | Wang, Jun-Zhi1; Yan, Xi-Ming1; Li, Zi-Cheng2; Luo, Hua-Jun1; Huang, Nian-Yu1; Deng, Wei-Qiao1,3 |
| 刊名 | medicinal chemistry research
 |
| 出版日期 | 2015-11-01 |
| 卷号 | 24期号:11页码:3813-3820 |
| 关键词 | Bisabolangelone Calcium channel Neurons Molecular docking |
| 英文摘要 | bisabolangelone is the main active ingredient of angelica polymorpha, which has the good pharmacological activities such as anti-celialgia, anti-dysmenorrhea and anti-gastralgia. in this study, the neuroprotective effect of bisabolangelone against hydrogen peroxide (h2o2)-induced neurotoxicity in human neuroblastoma cells was studied. the binding capacity between bisabolangelone and calcium channel was calculated by molecular docking method, and calcium concentration was detected by the calcium fluorescent probe of fura-2 am. the results indicated that bisabolangelone had a good neuroprotective effect on nerve cells by interacting with calcium channels, mainly blocking the voltage-gated calcium channels, suppressing calcium releasing from the calcium store. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | chemistry, medicinal |
| 研究领域[WOS] | pharmacology & pharmacy |
| 关键词[WOS] | calcium-channels ; parkinsons ; disease |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000361758000005 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/146560]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Hubei, Peoples R China 2.China Three Gorges Univ, Coll Med, Yichang 443002, Hubei, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jun-Zhi,Yan, Xi-Ming,Li, Zi-Cheng,et al. Neuroprotective effect of bisabolangelone on hydrogen peroxide-induced neurotoxicity in SH-SY5Y cells[J]. medicinal chemistry research,2015,24(11):3813-3820. |
| APA | Wang, Jun-Zhi,Yan, Xi-Ming,Li, Zi-Cheng,Luo, Hua-Jun,Huang, Nian-Yu,&Deng, Wei-Qiao.(2015).Neuroprotective effect of bisabolangelone on hydrogen peroxide-induced neurotoxicity in SH-SY5Y cells.medicinal chemistry research,24(11),3813-3820. |
| MLA | Wang, Jun-Zhi,et al."Neuroprotective effect of bisabolangelone on hydrogen peroxide-induced neurotoxicity in SH-SY5Y cells".medicinal chemistry research 24.11(2015):3813-3820. |
入库方式： OAI收割
来源：大连化学物理研究所
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