Synthesis of Chiral Trifluoromethyl-Substituted Hydrazines via Pd-Catalyzed Asymmetric Hydrogenation and Reductive Amination
文献类型：期刊论文
| 作者 | Chen, Zhang-Pei1; Hu, Shu-Bo1; Zhou, Ji1; Zhou, Yong-Gui1,2 |
| 刊名 | acs catalysis
 |
| 出版日期 | 2015-10-01 |
| 卷号 | 5期号:10页码:6086-6089 |
| 关键词 | palladium asymmetric hydrogenation reductive amination trifluoromethylated hydrazines Bronsted acid |
| 英文摘要 | an efficient approach toward the synthesis of cyclic and linear chiral trifluoromethyl substituted hydrazines was developed by pd-catalyzed asymmetric hydrogenation of both n-acyl and n-aryl hydrazones in excellent yields and up to 97% ee. a successful reductive amination between trifluormethyl substituted ketones and hydrazines was also achieved. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, physical |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | partially-modified retro ; enantioselective hydrogenation ; perfluoroalkylation reactions ; medicinal chemistry ; facile access ; ketones ; amines ; acid ; fluorination ; pyrazolidine |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000362391500046 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/146565]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Zhang-Pei,Hu, Shu-Bo,Zhou, Ji,et al. Synthesis of Chiral Trifluoromethyl-Substituted Hydrazines via Pd-Catalyzed Asymmetric Hydrogenation and Reductive Amination[J]. acs catalysis,2015,5(10):6086-6089. |
| APA | Chen, Zhang-Pei,Hu, Shu-Bo,Zhou, Ji,&Zhou, Yong-Gui.(2015).Synthesis of Chiral Trifluoromethyl-Substituted Hydrazines via Pd-Catalyzed Asymmetric Hydrogenation and Reductive Amination.acs catalysis,5(10),6086-6089. |
| MLA | Chen, Zhang-Pei,et al."Synthesis of Chiral Trifluoromethyl-Substituted Hydrazines via Pd-Catalyzed Asymmetric Hydrogenation and Reductive Amination".acs catalysis 5.10(2015):6086-6089. |
入库方式： OAI收割
来源：大连化学物理研究所
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