Fluorescent carbon dots from beer for breast cancer cell imaging and drug delivery
文献类型：期刊论文
| 作者 | Wang, Ziyi1,3; Liao, Han3; Wu, Hao3; Wang, Beibei3; Zhao, Haidong1; Tan, Mingqian2 |
| 刊名 | analytical methods
 |
| 出版日期 | 2015 |
| 卷号 | 7期号:20页码:8911-8917 |
| 英文摘要 | we report the finding of the presence of fluorescent carbon dots in commercial beer and tem analysis reveals that the beer carbon dots (bcds) have an average size of 2.5 nm. the bcds possessed high solubility and excellent fluorescence properties under the excitation of ultra-violet light with a quantum yield of approximately 7.39%. x-ray photoelectron spectroscopy (xps) characterization demonstrated that the bcds contain carbon, oxygen and nitrogen, three elements with the relative contents ca. 59.52%, 36.71% and 3.77%, respectively. x-ray diffraction (xrd) analysis indicated that the bcds are amorphous. fourier transform infrared (ftir) spectroscopy was employed to characterize the surface groups of the bcds. the bcds showed excellent stability under different conditions (high ion strength, extreme ph and laser exposure). the cytotoxicity study revealed that there was no obvious inhibition of cell viability with a concentration as high as 12.5 mg ml(-1) for 48 h, so that the bcds could be directly applied in live cell imaging. moreover, the bcds could be used as efficient nanocarriers for the purpose of anticancer therapy. doxorubicin-conjugated bcds (bcd-dox) induced prolonged cytotoxicity compared to free doxorubicin (dox) due to the slow release of dox from the bcd-dox. the internalization of bcd-dox by mcf-7 cells was further confirmed by using a laser scanning confocal microscope. all these results indicated that the bcds present in beer have good biocompatibility and excellent fluorescence properties and may be considered as a safe material for bio-imaging and image-guided drug delivery in cancer therapy. |
| WOS标题词 | science & technology ; physical sciences ; life sciences & biomedicine ; technology |
| 类目[WOS] | chemistry, analytical ; food science & technology ; spectroscopy |
| 研究领域[WOS] | chemistry ; food science & technology ; spectroscopy |
| 关键词[WOS] | multifunctional unimolecular micelles ; iron-oxide nanoparticles ; in-vivo ; magnetic-resonance ; doxorubicin ; nanodots ; photoluminescence ; nanotubes ; probes ; route |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000362662600056 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/146590]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Dalian Med Univ, Affiliated Hosp 2, Dalian 116023, Peoples R China 2.Dalian Polytech Univ, Sch Food Sci & Technol, Liaoning Key Lab Food Biol Technol, Dalian 116034, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Ziyi,Liao, Han,Wu, Hao,et al. Fluorescent carbon dots from beer for breast cancer cell imaging and drug delivery[J]. analytical methods,2015,7(20):8911-8917. |
| APA | Wang, Ziyi,Liao, Han,Wu, Hao,Wang, Beibei,Zhao, Haidong,&Tan, Mingqian.(2015).Fluorescent carbon dots from beer for breast cancer cell imaging and drug delivery.analytical methods,7(20),8911-8917. |
| MLA | Wang, Ziyi,et al."Fluorescent carbon dots from beer for breast cancer cell imaging and drug delivery".analytical methods 7.20(2015):8911-8917. |
入库方式： OAI收割
来源：大连化学物理研究所
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