The tribological properties of polyimide (PI) and PI/fluorinated graphene (FG) nanocomposites, as a new class of graphene reinforced polymer, are investigated using a ball-on-disk configuration under different lubricated conditions of dry sliding, water lubrication and oil lubrication. Experimental results reveal that single incorporation of FG can effectively improve the tribological performance of PI under all the three conditions. In addition, compared to the results under dry sliding, the phenomenon that the friction coefficient decreases while the wear rate increases under water lubrication condition is observed and researched in detail. The worst anti-wear performance under water-lubricated condition can be ascribed to the fact that the water can be adsorbed by the polar imide radicals of the PI and PI/FG nanocomposite, therefore leading to the property deterioration of the PI and PI/FG nanocomposite coatings.