Phytosteroids and triterpenoids with potent cytotoxicities from the leaves of Chisocheton cumingianus
文献类型：期刊论文
| 作者 | Huang, Shan-Shan ; Jian, Kai-Li ; Li, Rui-Jun ; Kong, Ling-Yi ; Yang, Ming-Hua |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2016 |
| 卷号 | 6期号:8页码:6320-6328 |
| ISSN号 | 2046-2069 |
| 关键词 | ABSOLUTE-CONFIGURATION DAMMARANE TRITERPENES OXIDATION-PRODUCTS CONSTITUENTS |
| 中文摘要 | Six phytosteroids and three dammarane-type triterpenoids, namely chisopanoids A-F (1-6) and chisopanones G-I (7-9), together with nine known triterpenoids (10-18) were isolated from the leaves of Chisocheton cumingianus. Their structures were elucidated by extensive spectroscopic analysis, X-ray crystallographic analysis, Mosher's method and Mo-2(OAc)(4)-induced electronic circular dichroism (ECD) data. All compounds were evaluated for their cytotoxicities against HepG2, U2OS and MCF-7 human cancer cell lines, as well as inhibitory effects on nitric oxide (NO) production in LPS-activated RAW 264.7 macrophages. Compounds 5 and 6 showed potent cytotoxicities towards MCF-7 with IC50 values of 3.24 +/- 1.39 and 8.85 +/- 4.73 mu M, and were further proved to inhibit the cell proliferation mainly by inducing apoptosis. |
| 收录类别 | SCI |
| 原文出处 | 10.1039/c5ra23626f |
| 语种 | 英语 |
| 公开日期 | 2016-05-12 |
| 源URL | [http://ir.xtbg.org.cn/handle/353005/9799]  |
| 专题 | 西双版纳热带植物园_文献共享 |
| 推荐引用方式 GB/T 7714 | Huang, Shan-Shan,Jian, Kai-Li,Li, Rui-Jun,et al. Phytosteroids and triterpenoids with potent cytotoxicities from the leaves of Chisocheton cumingianus[J]. RSC ADVANCES,2016,6(8):6320-6328. |
| APA | Huang, Shan-Shan,Jian, Kai-Li,Li, Rui-Jun,Kong, Ling-Yi,&Yang, Ming-Hua.(2016).Phytosteroids and triterpenoids with potent cytotoxicities from the leaves of Chisocheton cumingianus.RSC ADVANCES,6(8),6320-6328. |
| MLA | Huang, Shan-Shan,et al."Phytosteroids and triterpenoids with potent cytotoxicities from the leaves of Chisocheton cumingianus".RSC ADVANCES 6.8(2016):6320-6328. |
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来源：西双版纳热带植物园
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