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Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice

文献类型：期刊论文

作者Xia, D; Liu, B; Luan, XY; Sun, JY; Liu, NN; Qin, S; Du, ZN
刊名CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
出版日期2016-03-01
卷号34期号:2页码:399-404
关键词C-phycocyanin acute ethanol liver injury protective effect
ISSN号0254-4059
产权排序[Xia Dong; Du Zhenning] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China; [Liu Bing; Sun Junyan; Liu Nana; Qin Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Luan Xiying] Binzhou Med Univ, Sch Basic Med, Yantai 264003, Peoples R China
通讯作者Du, ZN (reprint author), Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China. ; Qin, S (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China. sqin@yic.ac.cn ; zhenning.du@163.com
英文摘要Excessive alcohol consumption leads to liver disease. Extensive evidence suggests that C-phycocyanin (C-PC), a chromophore phycocyanobilin derived from Spirulina platensis, exerts protective effects against chemical-induced organ damage. In this study, we investigated whether C-PC could protect against ethanol-induced acute liver injury. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), total cholesterol (CHOL), low-density lipoprotein (LDL), liver homogenate malondialdehyde (MDA), superoxide dismutase (SOD) content were measured, and pathological examination of liver sections were examined. C-PC showed obvious inhibitory effects on serum ALT, AST, TG, CHOL, LDL and MDA, and SOD content significantly increased in the liver. The structure of hepatic lobules was clear, liver sinus returned to normal, and liver cell cords were arranged in neat rows. Cloudiness, swelling, inflammatory cell infiltration and spotty necrosis of liver cells were significantly reduced. Therefore, C-PC can significantly protect against ethanol-induced acute liver injury.
研究领域[WOS]Marine & Freshwater Biology ; Oceanography
关键词[WOS]FATTY LIVER ; IN-VITRO ; DISEASE ; ANTIOXIDANT ; PROGRESSION ; HEALTH ; VIVO
收录类别SCI
语种英语
WOS记录号WOS:000371607000016
源URL[http://ir.yic.ac.cn/handle/133337/10838]  
专题烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
作者单位1.Yantai Univ, Sch Pharm
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat
3.Binzhou Med Univ, Sch Basic Med
推荐引用方式
GB/T 7714		 Xia, D,Liu, B,Luan, XY,et al. Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2016,34(2):399-404.
APA Xia, D.,Liu, B.,Luan, XY.,Sun, JY.,Liu, NN.,...&Du, ZN.(2016).Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,34(2),399-404.
MLA Xia, D,et al."Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 34.2(2016):399-404.

入库方式： OAI收割

来源：烟台海岸带研究所

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