Protective effects of C-phycocyanin on alcohol-induced subacute liver injury in mice
文献类型：期刊论文
| 作者 | Xia, D; Liu, B ; Xin, WY; Liu, TS; Sun, JY; Liu, NN; Qin, S; Du, ZN
|
| 刊名 | JOURNAL OF APPLIED PHYCOLOGY
 |
| 出版日期 | 2016-04-01 |
| 卷号 | 28期号:2页码:765-772 |
| 关键词 | C-phycocyanin Subacute ethanol liver injury Improves immunity Protective effect |
| ISSN号 | 0921-8971 |
| 产权排序 | [Xia, Dong; Du, Zhenning] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China; [Liu, Bing; Sun, Junyan; Liu, Nana; Qin, Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Xin, Wenyu; Liu, Tongshen] Binzhou Med Univ, Sch Basic Med, Yantai 264003, Peoples R China |
| 通讯作者 | Qin, S (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China. bliu@yic.ac.cn |
| 英文摘要 | Excessive and long-term alcohol consumption leads to liver disease and low immunity. Extensive evidence suggests that C-phycocyanin (C-PC), a chromophore phycocyanobilin derived from Arthrospira (Spirulina) platensis, exerts protective effects against chemical-induced organ damage and improves immunity. In this study, we investigated whether C-PC could protect against ethanol-induced subacute liver injury and improve immunity. KM mice with ethanol-induced liver injury were established, and animals were divided into three groups that were treated with high, medium, and low doses of C-PC. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), total cholesterol (CHOL), low-density lipoprotein (LDL), total bilirubin (TBIL), liver homogenate malondialdehyde (MDA), and superoxide dismutase (SOD) levels were measured. In addition, the number of thymus T cell subsets was assessed, and liver sections were examined pathologically. C-PC exhibited obvious inhibitory effects on serum ALT, AST, TG, CHOL, LDL, and MDA levels and increased SOD content significantly in the liver. C-PC also increased serum CD3+ and CD4+ cell activation and T cell proliferation significantly compared with the model group. The structure of the hepatic lobules was clear, the liver sinus returned to normal, and the liver cell cords were arranged in neat rows. Therefore, C-PC could protect against ethanol-induced subacute liver injury significantly. |
| 研究领域[WOS] | Biotechnology & Applied Microbiology ; Marine & Freshwater Biology |
| 关键词[WOS] | LIPID-PEROXIDATION ; CARBON-TETRACHLORIDE ; FATTY LIVER ; IN-VITRO ; CYTOCHROME-P450 2E1 ; SPIRULINA-PLATENSIS ; OXIDATIVE STRESS ; DISEASE ; RATS ; ETHANOL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000372256900006 |
| 源URL | [http://ir.yic.ac.cn/handle/133337/10849]  |
| 专题 | 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
| 作者单位 | 1.Yantai Univ, Sch Pharm 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat 3.Binzhou Med Univ, Sch Basic Med |
| 推荐引用方式 GB/T 7714 | Xia, D,Liu, B,Xin, WY,et al. Protective effects of C-phycocyanin on alcohol-induced subacute liver injury in mice[J]. JOURNAL OF APPLIED PHYCOLOGY,2016,28(2):765-772. |
| APA | Xia, D.,Liu, B.,Xin, WY.,Liu, TS.,Sun, JY.,...&Du, ZN.(2016).Protective effects of C-phycocyanin on alcohol-induced subacute liver injury in mice.JOURNAL OF APPLIED PHYCOLOGY,28(2),765-772. |
| MLA | Xia, D,et al."Protective effects of C-phycocyanin on alcohol-induced subacute liver injury in mice".JOURNAL OF APPLIED PHYCOLOGY 28.2(2016):765-772. |
入库方式： OAI收割
来源：烟台海岸带研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。