Binary release of ascorbic acid and lecithin from core-shell nanofibers on blood-contacting surface for reducing long-term hemolysis of erythrocyte
文献类型：期刊论文
| 作者 | Shi,Qiang; Fan,Qunfu; Ye,Wei; Hou,Jianwen; Wong,Shing-Chung; Xu,Xiaodong; Yin,Jinghua |
| 刊名 | colloids and surfaces b-biointerfaces
 |
| 出版日期 | 2015 |
| 卷号 | 125期号:17页码:28-33 |
| 关键词 | POLYMER FIBERS INITIATED ATRP MEMBRANE STORAGE HEMOGLOBIN LIPOSOMES MECHANISM FRAGILITY ADHESION DISEASE |
| 通讯作者 | shi,q |
| 英文摘要 | there is an urgent need to develop blood-contacting biomaterials with long-term anti-hemolytic capability. to obtain such biomaterials, we coaxially electrospin [ascorbic acid (aa) and lecithin]/poly (ethylene oxide) (peo) core-shell nanofibers onto the surface of styrene-b-(ethylene-co-butylene)-b-styrene elastomer (sebs) that has been grafted with poly (ethylene glycol) (peg) chains. our strategy is based on that the grafted layers of peg render the surface hydrophilic to reduce the mechanical injure to red blood cells (rbcs) while the aa and lecithin released from nanofibers on blood-contacting surface can actively interact with rbcs to decrease the oxidative damage to rbcs. we demonstrate that (aa and lecithin)/peo core-shell structured nanofibers have been fabricated on the peg grafted surface. the binary release of aa and lecithin in the distilled water is in a controlled manner and lasts for almost 5 days; during rbcs preservation, aa acts as an antioxidant and lecithin as a lipid supplier to the membrane of erythrocytes, resulting in low mechanical fragility and hemolysis of rbcs, as well as high deformability of stored rbcs. our work thus makes a new approach to fabricate blood-contacting biomaterials with the capability of long-term anti-hemolysis. (c) 2014 elsevier b.v. all rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-31 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/65173]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Shi,Qiang,Fan,Qunfu,Ye,Wei,et al. Binary release of ascorbic acid and lecithin from core-shell nanofibers on blood-contacting surface for reducing long-term hemolysis of erythrocyte[J]. colloids and surfaces b-biointerfaces,2015,125(17):28-33. |
| APA | Shi,Qiang.,Fan,Qunfu.,Ye,Wei.,Hou,Jianwen.,Wong,Shing-Chung.,...&Yin,Jinghua.(2015).Binary release of ascorbic acid and lecithin from core-shell nanofibers on blood-contacting surface for reducing long-term hemolysis of erythrocyte.colloids and surfaces b-biointerfaces,125(17),28-33. |
| MLA | Shi,Qiang,et al."Binary release of ascorbic acid and lecithin from core-shell nanofibers on blood-contacting surface for reducing long-term hemolysis of erythrocyte".colloids and surfaces b-biointerfaces 125.17(2015):28-33. |
入库方式： OAI收割
来源：长春应用化学研究所
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