A label-free electrochemical impedance aptasensor for cylindrospermopsin detection based on thionine-graphene nanocomposites
文献类型：期刊论文
| 作者 | Zhao,Zhen; Chen,Hongda; Ma,Lina; Liu,Dianjun; Wang,Zhenxin |
| 刊名 | analyst
 |
| 出版日期 | 2015 |
| 卷号 | 140期号:16页码:5570-5577 |
| 关键词 | GREEN-ALGAL TOXIN CYANOBACTERIAL TOXIN IN-VITRO WATER RACIBORSKII TOXICITY OPTIMIZATION VALIDATION CYANOTOXIN BIOSENSOR |
| 通讯作者 | ma,ln |
| 英文摘要 | it is important to develop methods to determine cylindrospermopsin (cyn) at trace levels since cyn is a kind of widespread cyanobacterial toxin in water sources. in this study, a label-free impedimetric aptasensor has been fabricated for detecting cyn. in this case, the amino-substituted aptamer of cyn was co-valently grafted onto the surface of the thionine-graphene (th-g) nanocomposite through the crosslinker glutaraldehyde (ga). the reaction of the aptamer with cyn was monitored by electrochemical impedance spectroscopy because the cyn induced conformation change of the aptamer can cause a remarkable decrease of the electron transfer resistance. under optimum conditions, the aptasensor exhibits high sensitivity and a low detection limit for cyn determination. the cyn can be quantified in a wide range of 0.39 to 78 ng ml(-1) with a good linearity (r-2 = 0.9968) and a low detection limit of 0.117 ng ml(-1). in addition, the proposed aptasensor displays excellent stability, reusability and reproducibility. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000358521400021 |
| 公开日期 | 2016-05-31 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/65187]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhao,Zhen,Chen,Hongda,Ma,Lina,et al. A label-free electrochemical impedance aptasensor for cylindrospermopsin detection based on thionine-graphene nanocomposites[J]. analyst,2015,140(16):5570-5577. |
| APA | Zhao,Zhen,Chen,Hongda,Ma,Lina,Liu,Dianjun,&Wang,Zhenxin.(2015).A label-free electrochemical impedance aptasensor for cylindrospermopsin detection based on thionine-graphene nanocomposites.analyst,140(16),5570-5577. |
| MLA | Zhao,Zhen,et al."A label-free electrochemical impedance aptasensor for cylindrospermopsin detection based on thionine-graphene nanocomposites".analyst 140.16(2015):5570-5577. |
入库方式： OAI收割
来源：长春应用化学研究所
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