Toxicity mechanism of graphene oxide and nitrogen-doped graphene quantum dots in RBCs revealed by surface-enhanced infrared absorption spectroscopy
文献类型：期刊论文
| 作者 | Wang,Tiantian; Zhu,Shoujun; Jiang,Xiue |
| 刊名 | toxicology research
 |
| 出版日期 | 2015 |
| 卷号 | 4期号:4页码:885-894 |
| 关键词 | CELLULAR UPTAKE RED-CELL ADENOSINE-TRIPHOSPHATE MULTIVARIATE-ANALYSIS CARBON NANOPARTICLES GOLD NANOPARTICLES HUMAN ERYTHROCYTES LIPID-MEMBRANES IN-VITRO NANOSHEETS |
| 通讯作者 | wang,tt |
| 英文摘要 | the study of the toxic effects of nanoparticles on biological systems at the molecular level is critical in order to gain a greater understanding of the origin of nanotoxicity. recently, numerous forms of graphene materials have been synthesized and extensively applied in biosensors and biomedicine, but their toxicity has not yet been studied to the same extend, in particular the toxicity mechanism. in this work, we systematically studied the toxic effects of two typical graphene forms, graphene oxide (go) and nitrogendoped graphene quantum dots (n-gqds), on red blood cells (rbcs) by testing their hemolytic activity, observing the morphological changes and detecting the atp content of rbcs after being exposed to the two nanomaterials. the toxicity mechanism was further revealed by investigating the structural changes of rbcs lipid by surface-enhanced infrared absorption spectroscopy using model membranes. a detailed analysis of the infrared spectra revealed that the adsorption of go destroys the integrity of a membrane by extracting the lipid bilayer, resulting in hemolysis and aberrant forms. in contrast, n-gqds just disturb the structure and conformation of the lipid, resulting in only aberrant cells. to date, this is the first experimental study which has revealed the toxicity mechanism of graphene materials in rbcs at the molecular level. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-31 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/67802]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wang,Tiantian,Zhu,Shoujun,Jiang,Xiue. Toxicity mechanism of graphene oxide and nitrogen-doped graphene quantum dots in RBCs revealed by surface-enhanced infrared absorption spectroscopy[J]. toxicology research,2015,4(4):885-894. |
| APA | Wang,Tiantian,Zhu,Shoujun,&Jiang,Xiue.(2015).Toxicity mechanism of graphene oxide and nitrogen-doped graphene quantum dots in RBCs revealed by surface-enhanced infrared absorption spectroscopy.toxicology research,4(4),885-894. |
| MLA | Wang,Tiantian,et al."Toxicity mechanism of graphene oxide and nitrogen-doped graphene quantum dots in RBCs revealed by surface-enhanced infrared absorption spectroscopy".toxicology research 4.4(2015):885-894. |
入库方式： OAI收割
来源：长春应用化学研究所
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