Poly(ornithine-co-arginine-co-glycine-co-aspartic Acid): Preparation via NCA Polymerization and its Potential as a Polymeric Tumor-Penetrating Agent
文献类型：期刊论文
| 作者 | Yu,Haiyang; Tang,Zhaohui; Zhang,Dawei; Song,Wantong; Duan,Taicheng; Gu,Jingkai; Chen,Xuesi |
| 刊名 | macromolecular bioscience
 |
| 出版日期 | 2015 |
| 卷号 | 15期号:6页码:829-838 |
| 关键词 | PEGYLATED LIPOSOMAL DOXORUBICIN DRUG-DELIVERY N-CARBOXYANHYDRIDES BIOMEDICAL APPLICATIONS SYNTHETIC POLYPEPTIDES IN-VITRO NANOPARTICLES IRGD CISPLATIN EFFICACY |
| 通讯作者 | tang,zh |
| 英文摘要 | a novel random copolypeptide of ornithine, arginine, glycine, and aspartic acid [poly(ornithine-co-arginine-co-glycine-co-aspartic acid), poly(o,r,g,d)] has been prepared through ring-opening polymerization of n--carbobenzoxy-l-ornithine n-carboxyanhydride [orn(cbz)-nca)], l-glycine n-carboxyanhydride (gly-nca) and -benzyl l-aspartate n-carboxyanhydride [asp(bn)-nca], following by subsequent deprotection and guanidization. the structure of poly(o,r,g,d) was confirmed by nuclear magnetic resonance (nmr) spectroscopy and gel permeation chromatography (gpc). low cytotoxicity of poly(o,r,g,d) was confirmed from mtt assay. the poly(o,r,g,d) contain some internal sequences of rxxr (x=o, r, g, or d) that could be proteolytically cleaved to expose the cryptic cendr element and bind to neuropilin-1. this would lead to vascular and tissue permeabilization. therefore trypsin-cleaved poly(o,r,g,d) increase the vascular leakage of evans blue from dermal microvessels at the injection site in vivo skin permeability assay. the intratumoral injection of the poly(o,r,g,d) significantly enhanced the concentration of cisplatin-loaded nanoparticles in mcf-7 solid tumors. these results show that poly(o,r,g,d) could increase the vascular leakage and tissue penetration of nanoparticles in a solid tumor and can be used as a potential polymeric tumor-penetrating agent. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-31 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/67805]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Yu,Haiyang,Tang,Zhaohui,Zhang,Dawei,et al. Poly(ornithine-co-arginine-co-glycine-co-aspartic Acid): Preparation via NCA Polymerization and its Potential as a Polymeric Tumor-Penetrating Agent[J]. macromolecular bioscience,2015,15(6):829-838. |
| APA | Yu,Haiyang.,Tang,Zhaohui.,Zhang,Dawei.,Song,Wantong.,Duan,Taicheng.,...&Chen,Xuesi.(2015).Poly(ornithine-co-arginine-co-glycine-co-aspartic Acid): Preparation via NCA Polymerization and its Potential as a Polymeric Tumor-Penetrating Agent.macromolecular bioscience,15(6),829-838. |
| MLA | Yu,Haiyang,et al."Poly(ornithine-co-arginine-co-glycine-co-aspartic Acid): Preparation via NCA Polymerization and its Potential as a Polymeric Tumor-Penetrating Agent".macromolecular bioscience 15.6(2015):829-838. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。